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Recombination Activating Gene 1 Proteins (RAG1)

The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Additionally we are shipping RAG1 Antibodies (32) and RAG1 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat RAG1 RAG1 84600  
RAG1 5896 P15918
RAG1 19373 P15919
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Top RAG1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

RAG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Recombination Activating Gene 1 (RAG1) Interaction Partners

Pig (Porcine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (show PRKDC Proteins)) phenotype similar to that of rodents and humans.

  2. Piglets with biallelic mutations in either RAG1 or RAG2 (show RAG2 Proteins) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.

Human Recombination Activating Gene 1 (RAG1) interaction partners

  1. study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (show PRKDC Proteins)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (show PRKDC Proteins) was seen in one patient

  2. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  3. These findings provide insight into the role of this poorly understood region of Rag1 and support the role of Rag1 in a post-cleavage stage of recombination

  4. Expression of recombinase RAG-1 in diabetic patients was detected primarily in alphabetaTCR+CD40 (show CD40 Proteins)+ lymphocytes.

  5. Bidirectional activity of the NWC promoter is responsible for RAG-2 (show RAG2 Proteins) transcription in non-lymphoid cells [NWC]

  6. This study reports on the prevalence of RAG1 and RAG2 (show RAG2 Proteins) mutations in ten severe combined immunodeficiency (show PRKDC Proteins) disorder patients in Egypt.

  7. compiled 751 genetic variants in human RAG1 gene using 1092 human genomes

  8. analysis of regions of RAG1 necessary for interaction with RAG2 (show RAG2 Proteins) and measurement of the RAG1-RAG2 (show RAG2 Proteins) binding affinity

  9. Investigate the factors that regulate RAG1 and RAG2 (show RAG2 Proteins) cleavage on non-B DNA structures. We find that RAG binding and cleavage on heteroduplex DNA is dependent on the length of the double-stranded flanking region.

  10. A hypomorphic recombination-activating gene 1 (RAG1) mutation resulting in a phenotype resembling common variable immunodeficiency

Mouse (Murine) Recombination Activating Gene 1 (RAG1) interaction partners

  1. propose that pre-B cells toggle between pre-BCR (show BCR Proteins) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes

  2. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  3. The non-core region of RAG1 facilitates chromosomal V(D)J recombination in a ubiquitylation-dependent pathway.

  4. Based on our results, we propose that interaction of RAG2 (show RAG2 Proteins) with RAG1 induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 interdomain boundary

  5. 12recombination signal sequences-23recombination signal sequences cooperation (the "12/23 rule") is important not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG1 and RAG2 (show RAG2 Proteins) recruitment to chromatin.

  6. ubiquitination of RAG1, which can be promoted by RAG1's own ubiquitin ligase activity, plays a significant role in governing the level of V(D)J recombination activity

  7. The complex RAG1/2 binds one copy each of 12 recombination signal sequence and 23 recombination signal sequence DNA.

  8. SATB1 (show SATB1 Proteins) binds to the ASE (show ARSE Proteins) and Rag promoters, facilitating inclusion of Rag2 (show RAG2 Proteins) in the chromatin hub and the loading of RNA polymerase II to both the Rag1 and Rag2 (show RAG2 Proteins) promoters.

  9. Study provides evidence that RAG expression (RAG1, RAG2 (show RAG2 Proteins))in uncommitted hematopoietic progenitors and NK cell precursors marks functionally distinct subsets of NK cells in the periphery, demonstrating both a novel role for RAG in the functional specialization of the NK cell lineage and a physiological role for RAG proteins outside of V(D)J recombination.

  10. Rag1 plays a role in optic neuropathy as a proapoptotic candidate in p50 (show LSP1 Proteins)-deficient mice.

Zebrafish Recombination Activating Gene 1 (RAG1) interaction partners

  1. first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen

  2. target-selected inactivation of the rag1 gene

  3. Rag1 has a role in developing zebrafish cortex-medullary regionalization

  4. by embryonic day 4, rag1 transcripts are seen in the pancreas

  5. Recombination signal sequences are recognized by rag1 protein.

  6. Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting

  7. This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).

RAG1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.

Gene names and symbols associated with RAG1

  • recombination activating gene 1 (Rag1)
  • recombination activating gene 1 (RAG1)
  • recombination activating gene 1 (rag1)
  • recombinase activating protein (RAG-1)
  • recombination activating gene 1 a (rag1)
  • rag-1 protein
  • rag1 protein
  • rag1a protein
  • RNF74 protein

Protein level used designations for RAG1

V(D)J recombination-activating protein 1 , recombination activation protein 1 , recombination activating gene 1 , recombination activating protein 1 , recombination-activating gene 1 , recombinase activating protein , V(D)J recombination-activating protein 1-like , RING finger protein 74 , recombinase activating gene 1 , etID309719.25 , recombinase , recombination activating protein

GENE ID SPECIES
84600 Rattus norvegicus
466489 Pan troglodytes
483420 Canis lupus familiaris
506302 Bos taurus
619389 Monodelphis domestica
697322 Macaca mulatta
100049810 Equus caballus
100077097 Ornithorhynchus anatinus
100145555 Xenopus (Silurana) tropicalis
100395720 Callithrix jacchus
100447109 Pongo abelii
100595879 Nomascus leucogenys
397506 Sus scrofa
5896 Homo sapiens
19373 Mus musculus
423164 Gallus gallus
100328950 Oryctolagus cuniculus
30663 Danio rerio
100136833 Oncorhynchus mykiss
100337558 Xenopus laevis
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