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The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Additionally we are shipping RAG1 Antibodies (32) and RAG1 Kits (31) and many more products for this protein.
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Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (show PRKDC Proteins)) phenotype similar to that of rodents and humans.
Piglets with biallelic mutations in either RAG1 or RAG2 (show RAG2 Proteins) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.
study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (show PRKDC Proteins)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (show PRKDC Proteins) was seen in one patient
Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.
These findings provide insight into the role of this poorly understood region of Rag1 and support the role of Rag1 in a post-cleavage stage of recombination
Expression of recombinase RAG-1 in diabetic patients was detected primarily in alphabetaTCR+CD40 (show CD40 Proteins)+ lymphocytes.
Bidirectional activity of the NWC promoter is responsible for RAG-2 (show RAG2 Proteins) transcription in non-lymphoid cells [NWC]
This study reports on the prevalence of RAG1 and RAG2 (show RAG2 Proteins) mutations in ten severe combined immunodeficiency (show PRKDC Proteins) disorder patients in Egypt.
compiled 751 genetic variants in human RAG1 gene using 1092 human genomes
analysis of regions of RAG1 necessary for interaction with RAG2 (show RAG2 Proteins) and measurement of the RAG1-RAG2 (show RAG2 Proteins) binding affinity
Investigate the factors that regulate RAG1 and RAG2 (show RAG2 Proteins) cleavage on non-B DNA structures. We find that RAG binding and cleavage on heteroduplex DNA is dependent on the length of the double-stranded flanking region.
A hypomorphic recombination-activating gene 1 (RAG1) mutation resulting in a phenotype resembling common variable immunodeficiency
propose that pre-B cells toggle between pre-BCR (show BCR Proteins) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes
The non-core region of RAG1 facilitates chromosomal V(D)J recombination in a ubiquitylation-dependent pathway.
Based on our results, we propose that interaction of RAG2 (show RAG2 Proteins) with RAG1 induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 interdomain boundary
12recombination signal sequences-23recombination signal sequences cooperation (the "12/23 rule") is important not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG1 and RAG2 (show RAG2 Proteins) recruitment to chromatin.
ubiquitination of RAG1, which can be promoted by RAG1's own ubiquitin ligase activity, plays a significant role in governing the level of V(D)J recombination activity
The complex RAG1/2 binds one copy each of 12 recombination signal sequence and 23 recombination signal sequence DNA.
SATB1 (show SATB1 Proteins) binds to the ASE (show ARSE Proteins) and Rag promoters, facilitating inclusion of Rag2 (show RAG2 Proteins) in the chromatin hub and the loading of RNA polymerase II to both the Rag1 and Rag2 (show RAG2 Proteins) promoters.
Study provides evidence that RAG expression (RAG1, RAG2 (show RAG2 Proteins))in uncommitted hematopoietic progenitors and NK cell precursors marks functionally distinct subsets of NK cells in the periphery, demonstrating both a novel role for RAG in the functional specialization of the NK cell lineage and a physiological role for RAG proteins outside of V(D)J recombination.
Rag1 plays a role in optic neuropathy as a proapoptotic candidate in p50 (show LSP1 Proteins)-deficient mice.
first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen
target-selected inactivation of the rag1 gene
Rag1 has a role in developing zebrafish cortex-medullary regionalization
by embryonic day 4, rag1 transcripts are seen in the pancreas
Recombination signal sequences are recognized by rag1 protein.
Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting
This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
V(D)J recombination-activating protein 1
, recombination activation protein 1
, recombination activating gene 1
, recombination activating protein 1
, recombination-activating gene 1
, recombinase activating protein
, V(D)J recombination-activating protein 1-like
, RING finger protein 74
, recombinase activating gene 1
, recombination activating protein