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RELN encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. Additionally we are shipping Reelin Kits (22) and Reelin Proteins (12) and many more products for this protein.
Showing 10 out of 53 products:
Mouse (Murine) Monoclonal Reelin Primary Antibody for IHC (p), IHC - ABIN153124
Saegusa, Woo, Fujimoto, Kemmochi, Shimamoto, Hirose, Mitsumori, Nishikawa, Shibutani: Sustained production of Reelin-expressing interneurons in the hippocampal dentate hilus after developmental exposure to anti-thyroid agents in rats. in Reproductive toxicology (Elmsford, N.Y.) 2010
Show all 10 references for ABIN153124
Human Monoclonal Reelin Primary Antibody for IHC (p), IP - ABIN153123
Ogawa, Wang, Ohishi, Taniai, Akane, Suzuki, Mitsumori, Shibutani: Reversible aberration of neurogenesis targeting late-stage progenitor cells in the hippocampal dentate gyrus of rat offspring after maternal exposure to acrylamide. in Archives of toxicology 2012
Developmental gene expression pattern of reelin, dab1 (show DAB1 Antibodies), vldlr (show VLDLR Antibodies), and apoer2 (show LRP8 Antibodies) in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.
A new transgenic mouse model demonstrates that Reelin is a molecule which is critical for proper cortical development.
androgenic hormones can influence cerebral reelin demethylation
data suggest Kdm5b (show KDM5B Antibodies) negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone.
reveals a novel function for Reelin/ApoER2 (show LRP8 Antibodies) in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
Reelin thus plays a role in restraining RAS and PI3-kinase (show PIK3CA Antibodies) promotion of cell motility and potentially tumour metastasis.
meprin alpha (show MEP1A Antibodies) and meprin beta (show MEP1B Antibodies) join the modulators of Reelin signalling as they cleave Reelin at a specific site and are upregulated under specific pathological conditions.
reelin and cofilin (show CFL1 Antibodies) cooperate in controlling cytoskeletal dynamics during neuronal migration.
Results suggest that Reelin induces branching of the leading processes of migrating neurons and that of basal processes of radial glial cells when they arrive at the Reelin-containing marginal zone.
Results revealed that lack of functional reelin does not simply invert, but highly disorganize visual cortical layers, resulting in a massive intermingling of cells with different laminar fates.
Report demonstrated that the reelin subregion R5-6 consisting of 747 amino acids in the 5th and 6th repeats was sufficient for apoER2 (show LRP8 Antibodies) and VLDLR (show VLDLR Antibodies) binding, and inhibiting lipoprotein-induced cholesterol accumulation in macrophages.
Among men, but not in women certain genotypes of the RELN gene were significantly associated with the susceptibility to Alzheimer's disease.
The features of reelin expression in the brain of fetuses and newborns at 22-40 weeks' gestation with internal HC should be considered as morphological differential and diagnostic criteria for the disease in relation to its etiology.
Study shows that early neural cells transiently express Reelin at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 (show DAB1 Antibodies) is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin.
the reelin protein blood concentration might be a relevant signal with respect to the pathophysiology of schizophrenia.
These findings suggest a central AKT (show AKT1 Antibodies)-FOXG1 (show FOXG1 Antibodies)-reelin signaling pathway in focal malformations of cortical development and support pathway inhibitors as potential treatments or therapies for some forms of focal epilepsy.
rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk.
RELN SNPs were associated with Alzheimer disease and mild cognitive impairment. GG genotype at rs2299356 was associated with risk of AD. RELN-rs528528 CT genotype was protective for MCI (show MCIN Antibodies).
pThis study roposed that RELN mutations contribute to the genetic heterogeneity of myoclonus-dystonia.
A peak in Reelin mRNA and protein expression is present in the pig embryonic brain during the period of major neurogenesis and neuronal migration.
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
, extracellular matrix serine protease
, reelin, extracellular