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Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. Additionally we are shipping REG4 Kits (52) and REG4 Antibodies (33) and many more products for this protein.
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Human REG4 Protein expressed in CHO Cells - ABIN2004056
Hartupee, Zhang, Bonaldo, Soares, Dieckgraefe: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. in Biochimica et biophysica acta 2001
Show all 3 references for ABIN2004056
Rat (Rattus) REG4 Protein expressed in Human Cells - ABIN2009377
Violette, Festor, Pandrea-Vasile, Mitchell, Adida, Dussaulx, Lacorte, Chambaz, Lacasa, Lesuffleur: Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. in International journal of cancer. Journal international du cancer 2002
Show all 3 references for ABIN2009377
Human REG4 Protein expressed in Human Cells - ABIN2004052
Kämäräinen, Heiskala, Knuutila, Heiskala, Winqvist, Andersson: RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. in The American journal of pathology 2003
Show all 3 references for ABIN2004052
Human REG4 Protein expressed in HEK-293 Cells - ABIN2181689
Ho, Lou, Wei, Luo, Lin, Lyu, Chen: Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. in Journal of molecular biology 2010
Show all 2 references for ABIN2181689
REG4 is a transcriptional target of GATA6 (show GATA6 Proteins) and is essential for colorectal tumorigenesis.
This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer.
aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion.
REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous
The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.
Colorectal tumor patients with Reg4- and MMP-7 (show MMP7 Proteins)-positive tumors had extremely poor overall survival.
High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant chemoradiotherapy.
miR (show MLXIP Proteins)-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4.
REG4 expression is common in mucinous borderline ovarian tumors of the intestinal type as it is absent in the endocervical-like form tumors.
the combination of VEGF-C (show VEGFC Proteins) and Reg IV may be a promising factor for clinical staging to supplement the classical TNM (show ODZ1 Proteins) classification system.
data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 (show BCL2 Proteins) and Bcl-xL (show BCL2L1 Proteins) via activation of the EGFR (show EGFR Proteins)/Akt (show AKT1 Proteins) signalling pathway.
Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.
reg4 is amplified in the early stages of pancreatic cancer development
Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.
Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).
, regenerating islet-derived protein 4
, REG-like protein
, gastrointestinal secretory protein
, reg IV
, regenerating gene type IV
, regenerating islet-derived protein IV