You are viewing an incomplete version of our website. Please click to reload the website as full version.

Regenerating Islet-Derived Family, Member 4 Proteins (REG4)

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. Additionally we are shipping REG4 Kits (52) and REG4 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
REG4 445583 Q68AX7
REG4 83998 Q9BYZ8
REG4 67709 Q9D8G5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top REG4 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_CHO Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$528.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

REG4 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
,
Human , , , , , ,
, , ,
Mouse (Murine) ,

Top referenced REG4 Proteins

  1. Human REG4 Protein expressed in CHO Cells - ABIN2004056 : Hartupee, Zhang, Bonaldo, Soares, Dieckgraefe: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. in Biochimica et biophysica acta 2001 (PubMed)
    Show all 3 references for ABIN2004056

  2. Rat (Rattus) REG4 Protein expressed in Human Cells - ABIN2009377 : Violette, Festor, Pandrea-Vasile, Mitchell, Adida, Dussaulx, Lacorte, Chambaz, Lacasa, Lesuffleur: Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. in International journal of cancer. Journal international du cancer 2002 (PubMed)
    Show all 3 references for ABIN2009377

  3. Human REG4 Protein expressed in Human Cells - ABIN2004052 : Kämäräinen, Heiskala, Knuutila, Heiskala, Winqvist, Andersson: RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. in The American journal of pathology 2003 (PubMed)
    Show all 3 references for ABIN2004052

  4. Human REG4 Protein expressed in HEK-293 Cells - ABIN2181689 : Ho, Lou, Wei, Luo, Lin, Lyu, Chen: Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. in Journal of molecular biology 2010 (PubMed)
    Show all 2 references for ABIN2181689

More Proteins for Regenerating Islet-Derived Family, Member 4 (REG4) Interaction Partners

Human Regenerating Islet-Derived Family, Member 4 (REG4) interaction partners

  1. Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB (show CREB1 Proteins).

  2. REG4 is a transcriptional target of GATA6 (show GATA6 Proteins) and is essential for colorectal tumorigenesis.

  3. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer.

  4. aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion.

  5. REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous

  6. The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.

  7. Colorectal tumor patients with Reg4- and MMP-7 (show MMP7 Proteins)-positive tumors had extremely poor overall survival.

  8. High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant chemoradiotherapy.

  9. miR (show MLXIP Proteins)-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4.

  10. REG4 expression is common in mucinous borderline ovarian tumors of the intestinal type as it is absent in the endocervical-like form tumors.

Mouse (Murine) Regenerating Islet-Derived Family, Member 4 (REG4) interaction partners

  1. data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 (show BCL2 Proteins) and Bcl-xL (show BCL2L1 Proteins) via activation of the EGFR (show EGFR Proteins)/Akt (show AKT1 Proteins) signalling pathway.

  2. Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.

  3. reg4 is amplified in the early stages of pancreatic cancer development

  4. Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.

REG4 Protein Profile

Protein Summary

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity).

Gene names and symbols associated with REG4

  • regenerating islet-derived family, member 4 (Reg4)
  • regenerating islet-derived family, member 4 (REG4)
  • 2010002L15Rik protein
  • GISP protein
  • REG-IV protein
  • RELP protein

Protein level used designations for REG4

REG-4 , regenerating islet-derived protein 4 , REG-like protein , gastrointestinal secretory protein , reg IV , regenerating gene type IV , regenerating islet-derived protein IV

GENE ID SPECIES
445583 Rattus norvegicus
83998 Homo sapiens
67709 Mus musculus
100154580 Sus scrofa
767907 Bos taurus
100727547 Cavia porcellus
424379 Gallus gallus
Selected quality suppliers for REG4 Proteins (REG4)
Did you look for something else?