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The protein encoded by RGN is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. Additionally we are shipping Regucalcin Proteins (23) and Regucalcin Kits (16) and many more products for this protein.
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SMP30/RGN is important for liver proliferation and tumorigenesis.
Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt (show AKT1 Antibodies) activation.
This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db (show LEPR Antibodies) mice.
SMP30/GNL-positive cells localized around the central veins of livers of mice and decreased numerically with aging. Nuclear SMP30/GNL protein might be a regulatory factor specific for genes whose expression governs transcription and the aging process.
SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.
SMP30 plays an important role in the regulation of coronary vascular tone by myocardium.
These results suggested that SMP30 might be involved in overriding the apoptotic homeostatic mechanism in response to DNA damage.
SMP30 deficiency is closely associated with non-alcoholic fatty liver disease pathogenesis.
left ventricular ejection fraction was more severely reduced in the DOX-treated SMP30 KO mice than in the DOX-treated WT mice, but was preserved in the DOX-treated SMP30 TG mice
Results from using this unique model of AA deficiency, the SMP30/GNL-KO mouse, now provide new information about formerly unknown AA functions that will implement further study of AA in vivo.
SMP30/gluconolactonase mRNA transcripts were detected in the ovaries of mice, and the expression of these transcripts increased from days 0 to 8 of gestation and decreased rapidly thereafter.
the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 (show TP53 Antibodies) and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome.
Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways.
Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase (show GLB1 Antibodies) expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis.
data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells.
immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients
results highlighted the importance of RGN as a regulatory protein in Ca2 (show CA2 Antibodies)+-dependent signaling pathways and its deregulation of RGN expression by Ca2 (show CA2 Antibodies)+o may contribute for onset and progression of PCa (show FLVCR1 Antibodies).
This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review]
The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues.
RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland.
SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor.
estrogen administration down-regulated RGN gene expression in the accessory sex glands of veal calves and beef cattle, while androgen treatment reduced RGN gene expression only in the testis.
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
, regucalcin (senescence marker protein-30)
, senescence marker protein 30
, senescence marker protein-30