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P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B\; MIM 600431) and may have a role in cell cycle regulation (Liu et al., 2002 [PubMed 12470661]).[supplied by OMIM, Mar 2008].. Additionally we are shipping RPRD1A Proteins (8) and many more products for this protein.
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Human Monoclonal RPRD1A Primary Antibody for WB - ABIN393464
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 3 references for ABIN393464
Data suggest that p15RS (p15INK4b (show CDKN2B Antibodies)-related sequence) acts as an intrinsic transcriptional repressor for Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-mediated gene transcription through recruiting HDAC2 (show HDAC2 Antibodies) histone deacetylase (show HDAC1 Antibodies).
RPRD1A and RPRD1B (show RPRD1B Antibodies) associate directly with RPAP2 (show RPAP2 Antibodies) phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2 (show RPAP2 Antibodies).
The p15RS expression specifically downregulates the expression of cathepsin B (show CTSB Antibodies) and MMP-9 (show MMP9 Antibodies) at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins.
p15RS inhibits Wnt (show WNT2 Antibodies) signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt (show WNT2 Antibodies) signaling initiates downstream gene expression by removing p15RS from promoters.
molecular cloning and characterization of P15RS, a novel P15(INK4b (show CDKN2B Antibodies)) related gene involved in G1/S progression
P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B\; MIM 600431) and may have a role in cell cycle regulation (Liu et al., 2002
regulation of nuclear pre-mRNA domain containing 1A
, regulation of nuclear pre-mRNA domain containing 1B
, Regulation of nuclear pre-mRNA domain containing 1A
, regulation of nuclear pre-mRNA domain containing 1B b
, Cyclin-dependent kinase inhibitor 2B-related protein (p15INK4B-related protein)
, cyclin-dependent kinase 2B-inhibitor-related protein
, p15INK4B-related protein
, regulation of nuclear pre-mRNA domain-containing protein 1A
, cyclin-dependent kinase inhibitor 2B-related protein
, Cyclin-dependent kinase inhibitor 2B-related protein