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Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Additionally we are shipping Regulation of Nuclear Pre-MRNA Domain Containing 1B Antibodies (41) and many more products for this protein.
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a detailed description of proteins associating with K-H/RPRD1B in higher-order protein complexes is required to further elucidate its role in various cellular processes
CREPT displays unique immunostaining for retroperitoneal leiomyosarcoma tissue and can be used to supplement other currently available markers.
study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt (show WNT2 Proteins) signaling.
RPRD1A (show RPRD1A Proteins) and RPRD1B associate directly with RPAP2 (show RPAP2 Proteins) phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2 (show RPAP2 Proteins).
RPRD1B overexpression promotes tumor growth and accelerates cell cycle progression.
This study reports that K-H functions in RNAPII regulation, and aids in stabilizing interactions between transcription termination factors, localizing Xrn2 (show XRN2 Proteins) to the 3'-end of genes and ultimately suppressing R-loop formation.
CREPT increases cyclin D1 (show CCND1 Proteins) transcription during tumorigenesis.
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation (By similarity).
regulation of nuclear pre-mRNA domain-containing protein 1B
, unm hi3400
, un-named hi3400
, regulation of nuclear pre-mRNA domain containing 1B
, regulation of nuclear pre-mRNA domain containing 1B a
, Regulation of nuclear pre-mRNA domain containing 1B
, cell cycle-related and expression-elevated protein in tumor
, cell-cycle related and expression-elevated protein in tumor