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Regulator of Calcineurin 1 Proteins (RCAN1)

The protein encoded by RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Additionally we are shipping Regulator of Calcineurin 1 Antibodies (162) and Regulator of Calcineurin 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RCAN1 1823 Q08554
RCAN1 54720 Q9JHG6
Rat RCAN1 RCAN1 266766 Q6IN33
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Top Regulator of Calcineurin 1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$467.86
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 3 to 4 Days
$4,009.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RCAN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Regulator of Calcineurin 1 (RCAN1) Interaction Partners

Xenopus laevis Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.

Human Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (show CHDH Proteins)) susceptibility.

  2. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease

  3. RCAN1 can interact with IkappaBalpha (show NFKBIA Proteins) and affect the phosphorylation of IkappaBalpha (show NFKBIA Proteins) at tyrosine 42.

  4. The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD (show CHDH Proteins), at least in the current research population.

  5. E4BP4 (show NFIL3 Proteins) and BIM (show BCL2L11 Proteins) regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1

  6. Rcan1-1L may play a protective role in Ang II (show AGT Proteins)-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.

  7. Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.

  8. Data show that after IL-1beta (show IL1B Proteins) treatment, the levels of reactive oxygen species and interleukin 8 (IL-8 (show IL8 Proteins)) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.

  9. Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta (show APP Proteins) production

  10. These results suggest that USP22 (show USP22 Proteins) positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes.

Mouse (Murine) Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. These results uncover a critical link between calcineurin (show PPP3CA Proteins) signalling, impaired neurotrophin (show BDNF Proteins) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.

  2. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.

  3. inhibition of the calcineurin (show PPP3CA Proteins)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo

  4. PACAP (show ADCYAP1 Proteins) targets RCAN1 to control neuronal differentiation.

  5. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (show NFATC1 Proteins)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (show PPP3CA Proteins) activity in HEK293T cells

  6. found that RCAN1/3 interact with RAF (show RAF1 Proteins) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (show RAF1 Proteins) kinases may influence T cell positive selection

  7. Calcineurin (show PPP3CA Proteins) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.

  8. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation.

  9. A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.

  10. SCF (show KITLG Proteins)-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF (show KITLG Proteins)-induced activation of calcineurin (show PPP3CA Proteins) & NF-kappaB (show NFKB1 Proteins), & negatively regulates its own expression via Egr1 (show EGR1 Proteins).

Regulator of Calcineurin 1 (RCAN1) Protein Profile

Protein Summary

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Gene names and symbols associated with RCAN1

  • regulator of calcineurin 1 (RCAN1)
  • regulator of calcineurin 1b (rcan1b)
  • Down syndrome critical region gene 1 (dscr1)
  • regulator of calcineurin 1 (rcan1)
  • desmocollin 1 (DSC1)
  • DSCR1-like protein (LOC443255)
  • regulator of calcineurin 1 (Rcan1)
  • 2410048A02Rik protein
  • AA408855 protein
  • Adapt78 protein
  • AI429645 protein
  • AL024459 protein
  • AV028423 protein
  • CALP1L protein
  • CDHF1 protein
  • CSP1 protein
  • DG2/DG3 protein
  • DSC1 protein
  • Dscr1 protein
  • Mcip1 protein
  • MGC53636 protein
  • MGC69428 protein
  • rcan1 protein
  • RCN1 protein
  • wu:fr92c05 protein

Protein level used designations for RCAN1

regulator of calcineurin 1 , Down syndrome critical region gene 1 , cadherin family member 1 , desmocollin-1 , desmosomal glycoprotein 2/3 , calcipressin-1 , down syndrome critical region protein 1 , Down syndrome candidate region 1 , calcium and oxidant-inducible mRNA , modulatory calcineurin-interacting protein 1 , myocyte-enriched calcineurin-interacting protein 1 , near DSCR proline-rich protein , Down syndrome critical region homolog 1 , calcineurin inhibitor , calcipressin 1 , down syndrome critical region protein 1 homolog , myocyte-enriched calcineurin interactin protein 1 , Down syndrome critical region protein 1 homolog , Oxidative-induced protein Adapt78

GENE ID SPECIES
697108 Macaca mulatta
336348 Danio rerio
380353 Xenopus laevis
448016 Xenopus (Silurana) tropicalis
1823 Homo sapiens
443255 Ovis aries
1827 Homo sapiens
54720 Mus musculus
379550 Xenopus laevis
418510 Gallus gallus
607887 Canis lupus familiaris
539640 Bos taurus
266766 Rattus norvegicus
100171642 Pongo abelii
100689474 Cricetulus griseus
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