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Required for completion of mitosis and cytokinesis (By similarity). Additionally we are shipping Regulator of Chromosome Condensation 2 Antibodies (60) and many more products for this protein.
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Impaired RCC2 affects functional and clinical endpoints of colorectal cancer. High-risk patients with either MSI (show MSI1 Proteins) or MSS (show SIL1 Proteins) tumors can be identified with cost-effective routine RCC2 assays.
RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (show RACGAP1 Proteins) RalA (show rala Proteins). RCC2 and RalA (show rala Proteins) apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
MiR (show MLXIP Proteins)-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2.
TD-60 is an essential regulator of cell cycle (show C13orf15 Proteins) progression during interphase.
a complex containing cortactin (show CTTN Proteins) and RCC2/TD60 complex that may play a functional role in cells undergoing mitosis.
Studies indicated that DDX21 (show DDX21 Proteins), HNRNPC (show HNRNPC Proteins), and RCC2 were isolated from Ku86 (show XRCC5 Proteins) multicomponent complex in response to DNA damage.
Data show that TD-60 is a member of the RCC1 family and that it binds preferentially the nucleotide-free form of the small G protein Rac1.
Dysregulation of Rac1 and Arf6 (show ARF6 Proteins) function by RCC2 knockdown also abolished persistent migration along fibronectin (show FN1 Proteins) fibers, indicating a functional role for RCC2 in directional cell movement.
Required for completion of mitosis and cytokinesis (By similarity).
regulator of chromosome condensation 2
, RCC1-like protein TD-60
, protein RCC2
, telophase disk protein of 60 kDa
, protein RCC2 homolog
, telophase disc 60 kDa protein