You are viewing an incomplete version of our website. Please click to reload the website as full version.

Regulator of G-Protein Signaling 4 Proteins (RGS4)

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. Additionally we are shipping RGS4 Antibodies (67) and RGS4 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RGS4 5999 P49798
RGS4 19736 O08899
RGS4 29480 P49799
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top RGS4 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,500.67
Details

RGS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced RGS4 Proteins

  1. Human RGS4 Protein expressed in Escherichia coli (E. coli) - ABIN667516 : Chowdari, Mirnics, Semwal, Wood, Lawrence, Bhatia, Deshpande, B K, Ferrell, Middleton, Devlin, Levitt, Lewis, Nimgaonkar: Association and linkage analyses of RGS4 polymorphisms in schizophrenia. in Human molecular genetics 2002 (PubMed)
    Show all 2 references for ABIN667516

  2. Human RGS4 Protein expressed in Wheat germ - ABIN1317968 : Rivero, Gabilondo, García-Sevilla, La Harpe, Morentín, Javier Meana: Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. in Neurochemistry international 2010 (PubMed)

More Proteins for Regulator of G-Protein Signaling 4 (RGS4) Interaction Partners

Human Regulator of G-Protein Signaling 4 (RGS4) interaction partners

  1. All of these results confirmed the critical role of RGS4 in NSCLC progression.

  2. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR

  3. RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events.

  4. RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.

  5. RGS4 and COMT (show COMT Proteins) risk variants are associated with brain structural alterations in patient with schizophrenia.

  6. genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA.

  7. ectopic expression of R4 subfamily members RGS2 (show RGS2 Proteins), RGS3 (show RGS3 Proteins), RGS4, and RGS5 (show RGS5 Proteins) reduced activated PAR1 (show MARK2 Proteins) wild-type signaling, whereas signaling by the PAR1 (show MARK2 Proteins) AKKAA mutant was minimally affected.

  8. Data indicate that Rab5 (show RAB5A Proteins), Rab7 (show RAB7B Proteins) and Rab11 (show RAB11A Proteins) are involved in RGS4 traffics through plasma membrane recycling or endosome.

  9. The results suggest unaltered membrane RGS4 and cytosolic RGS10 (show RGS10 Proteins) proteins levels in schizophrenia and major depression.

  10. dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants

Rabbit Regulator of G-Protein Signaling 4 (RGS4) interaction partners

  1. Activation of MEKK1 (show MAP3K1 Proteins)-MKK4 (show MAP2K4 Proteins)-JNK (show MAPK8 Proteins)-AP1 (show JUN Proteins) signaling pathway plays a tonic inhibitory role in regulating Rgs4 transcription in rabbit colonic smooth muscle cells.

  2. These findings suggest that 3'-most AU-rich elements sites within RGS4 3'-UTR are essential for the instability of RGS4 mRNA.

  3. The 5'-untranslated region (UTR) extended 120 bp nucleotides upstream of the Rgs4 start codon; a putative promoter sequence (1389 bp) showed a consensus TATA box and cis (show CISH Proteins)-acting binding sites for several potential transcriptional factors.

  4. The canonical IKK2 (show IKBKB Proteins)/IkappaBalpha (show NFKBIA Proteins) pathway of NF-kappaB (show NFKB1 Proteins) activation mediates the up-regulation of RGS4 expression in response to IL-1beta (show IL1B Proteins).

  5. Upregulation of RGS4 expression by IL-1beta (show IL1B Proteins) in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK (show MAPK14 Proteins) and inhibited by the PI3K/Akt (show AKT1 Proteins)/GSK3beta pathway.

Mouse (Murine) Regulator of G-Protein Signaling 4 (RGS4) interaction partners

  1. RGS4 in the paraventricular nucleus regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.

  2. Thus, RGS4 expression, specific to renal vascular smooth muscle cells, inhibits angiotensin II-mediated cytokine signaling and macrophage recruitment during reperfusion, distinct from vasomotor regulation.

  3. Spinal RGS4 inhibited the endogenous or exogenous OR-mediated antinociceptive effect in the formalin pain test.

  4. RGS6 (show RGS6 Proteins)-Gbeta5 (show GNB5 Proteins), but not RGS4, is the primary RGS (show PITX2 Proteins) modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.

  5. dramatic up-regulation of RGS4 expression in the nucleus accumbens of mice treated with monoamine-directed antidepressants

  6. RGS4 expression in mouse embryo is regulated by Lmx1a (show LMX1A Proteins) transcription factor.

  7. A novel nitric oxide-RGS4 signal pathway mechanism that couples cardiac vessel growth with myocyte growth and heart size.

  8. Findings support the concept that the inhibitory effects of SPL (show SGPL1 Proteins) on M3R (show CHRM3 Proteins) activity are mediated by RGS4.

  9. Rgs4 is expressed in endocrine progenitors of both zebrafish and mouse, and its expression in the mouse pancreatic epithelium is strictly dependent upon Ngn3 (show NEUROG3 Proteins), and loss of function of Rgs4 results in islet fragmentation in both organisms.

  10. RGS4 antagonizes the development of renal dysfunction in response to ischemia reperfusion injury.

RGS4 Protein Profile

Protein Summary

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with RGS4

  • regulator of G-protein signaling 4 (RGS4)
  • regulator of G-protein signaling 4 (Rgs4)
  • AA004315 protein
  • AA597169 protein
  • ESTM48 protein
  • ESTM50 protein
  • RGP4 protein
  • SCZD9 protein

Protein level used designations for RGS4

schizophrenia disorder 9 , regulator of G-protein signalling 4 , RGP4

GENE ID SPECIES
5999 Homo sapiens
488666 Canis lupus familiaris
617437 Bos taurus
100009014 Oryctolagus cuniculus
19736 Mus musculus
29480 Rattus norvegicus
100717645 Cavia porcellus
100157437 Sus scrofa
100381246 Ovis aries
378901 Gallus gallus
100172418 Pongo abelii
Selected quality suppliers for RGS4 Proteins (RGS4)
Did you look for something else?