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Regulator of G-Protein Signaling 6 Proteins (RGS6)

RGS6 encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. Additionally we are shipping RGS6 Antibodies (22) and RGS6 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RGS6 9628 P49758
RGS6 50779 Q9Z2H2
RGS6 54295  
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Top RGS6 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,069.83
Details

RGS6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Regulator of G-Protein Signaling 6 (RGS6) Interaction Partners

Human Regulator of G-Protein Signaling 6 (RGS6) interaction partners

  1. No significant association between SNPs of RGS6 and central adiposity has been found.

  2. reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker

  3. these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target.

  4. we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes.

  5. genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype

  6. RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins

  7. interacts with SCG10 (show STMN2 Proteins) and promotes neuronal differentiation; role of the G gamma subunit-like (GGL (show GGT5 Proteins)) domain of this protein

  8. Role of the RGS (show PITX2 Proteins) domain in stress-induced trafficking of RGS6 protein

  9. RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL (show GGT5 Proteins)) domain in subcellular localization of RGS6 splice variants

  10. RGS6 is the first member of the RGS (show PITX2 Proteins) protein family shown to interact with proteins involved in transcriptional regulation.

Mouse (Murine) Regulator of G-Protein Signaling 6 (RGS6) interaction partners

  1. The genetic loss of Rgs6 is associated with three phenotypes each individually associated with midbrain dopaminergic neuron neuron degeneration.

  2. propose that inhibition of RGS6 might represent a viable means to reduce alcohol cravings and withdrawal in human patients, while simultaneously protecting the heart and liver from further damage upon relapse

  3. RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60 (show KAT5 Proteins)-mediated Dnmt1 (show DNMT1 Proteins) degradation and promoting apoptosis

  4. Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.

  5. Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor (show CC2D1A Proteins)-adenylyl cyclase (AC) axis.

  6. RGS6-Gbeta5 (show GNB5 Proteins), but not RGS4 (show RGS4 Proteins), is the primary RGS (show PITX2 Proteins) modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.

  7. Spontaneous tumor formation was also seen in old female RGS6(-/-) but not in wild-type mice.

  8. results identify RGS6 as an essential mediator of the pathogenic responses to doxorubicin in heart, and they argue that RGS6 inhibition offers a rational means to circumvent doxorubicin cardiotoxicity in human patients with cancer

  9. establish RGS6 as a key component of GABA(B)R signaling

  10. Regulator of G-protein signaling 6 (RGS6) is a previously unrecognized, but essential, negative regulator of parasympathetic activation in heart.

RGS6 Protein Profile

Protein Summary

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.

Gene names and symbols associated with RGS6

  • regulator of G-protein signaling 6 (RGS6)
  • regulator of G-protein signaling 6 (Rgs6)
  • regulator of G-protein signaling 6 (rgs6)
  • regulator of G-protein signalling 6 (rgs6)
  • DKFZp459O0734 protein
  • GAP protein
  • hm:zeh0300 protein
  • RGS6 protein
  • si:ch211-268e23.2 protein

Protein level used designations for RGS6

regulator of G-protein signaling 6 , regulator of G-protein signalling 6 , regulator of G-protein signaling 6-like , GTPase activating protein , H_DJ1108A12.1 , S914 , WUGSC:H_DJ0283M22.1 , WUGSC:H_DJ1108A12.1

GENE ID SPECIES
453009 Pan troglodytes
517545 Bos taurus
694620 Macaca mulatta
100024815 Monodelphis domestica
100055109 Equus caballus
100172360 Pongo abelii
100387876 Callithrix jacchus
100549212 Meleagris gallopavo
100579925 Nomascus leucogenys
9628 Homo sapiens
50779 Mus musculus
54295 Rattus norvegicus
734690 Xenopus laevis
395618 Gallus gallus
562667 Danio rerio
480380 Canis lupus familiaris
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