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RGS12 encodes a member of the 'regulator of G protein signaling' (RGS) gene family. Additionally we are shipping RGS12 Antibodies (16) and RGS12 Proteins (4) and many more products for this protein.
RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL (show TNFSF11 ELISA Kits).
Rgs12 mutant mice had growth retardation with the phenotype of increased bone mass.
RGS12 splice variants exhibit differential spatiotemporal patterns of expression during postimplantation embryogenesis, suggesting nonoverlapping roles
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.
regulator of G-protein signaling 12
, regulator of G-protein signalling 12