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RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Additionally we are shipping Regulatory Factor X, 1 (Influences HLA Class II Expression) Antibodies (41) and many more products for this protein.
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Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells.
regulatory factor 1 directly regulates CD44 (show CD44 Proteins) expression in glioblastoma
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs (show TWIST1 Proteins).
RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK (show EPHB2 Proteins) signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.
NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis (show CISH Proteins)-regulatory elements.
in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter.
RFX1 recruits SUV39H1 (show SUV39H1 Proteins) to the promoter regions of the CD11a (show ITGAL Proteins) and CD70 (show CD70 Proteins) genes in CD4 (show CD4 Proteins)(+) T cells, thereby regulating local H3K9 tri (show VANGL2 Proteins)-methylation levels.
We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transc
RFX1 may negatively regulate the self-renewal of GBM-SCs (show TWIST1 Proteins) through modulating FGF-1B and FGF1 (show FGF1 Proteins) expression levels by binding the 18-bp cis (show CISH Proteins)-elements of the F1B promoter.
Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A (show MAP1A Proteins)) gene are important for effective transcriptional repression in non-neuronal cells.
This study suggests that ciliogenic Rfx transcription factors regulate Msi1 (show MSI1 Proteins) expression in neural stem/progenitor cells.
RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter.
Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.
These results suggest a significant expression of RFX1 proteins in the mammalian brain.
RFX1 may play roles in haploid cells during mouse spermatogenesis
RFX1 mediates the immediate early (show JUN Proteins) response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells.
RFX1 regulates expression of genes that are essential for early embryonic development/survival and that RFX1 function can not be compensated by other RFX1 family members.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
MHC class II regulatory factor RFX
, MHC class II regulatory factor RFX1
, enhancer factor C
, regulatory factor X 1
, trans-acting regulatory factor 1
, transcription factor RFX1
, vregulatory factor X, 1 (influences HLA class II expression)
, regulatory factor X1