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Regulatory Factor X 5 Proteins (RFX5)

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). Additionally we are shipping RFX5 Antibodies (90) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RFX5 5993 P48382
RFX5 53970  
Rat RFX5 RFX5 310659  
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Top RFX5 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RFX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Regulatory Factor X 5 (RFX5) Interaction Partners

Human Regulatory Factor X 5 (RFX5) interaction partners

  1. Data show arginine methyltransferase PRMT6 (show PRMT6 Proteins) methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression.

  2. these data have identified as novel pathway whereby SIRT1 (show SIRT1 Proteins) maintains COL1A2 (show COL1A2 Proteins) synthesis in SMCs by modulating RFX5 activity.

  3. RFXAP (show RFXAP Proteins)(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple.

  4. interaction at COL1A2 (show COL1A2 Proteins) start site and transcription repression

  5. The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function.

  6. RFX5 binds to the collagen transcription start site and represses collagen gene expression

  7. The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression.

  8. results demonstrate that RFX1 (show RFX1 Proteins) and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis

  9. PPARgamma (show PPARG Proteins) is within the RFX5.CIITA (show CIITA Proteins) complex as judged by co-immunoprecipitation and DNA affinity precipitation studies

  10. RFXAP (show RFXAP Proteins) and RFXB (show RFXANK Proteins) have roles in relieving autoinhibition of RFX5

Mouse (Murine) Regulatory Factor X 5 (RFX5) interaction partners

  1. TSA (show PRDX2 Proteins) treatment enhances the association of CIITA (show CIITA Proteins) with the transcription factor RFX5, which ameliorates the down-regulation of CIITA (show CIITA Proteins) recruitment to target promoters by HDAC2 (show HDAC2 Proteins).

RFX5 Protein Profile

Protein Summary

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

Gene names and symbols associated with Regulatory Factor X 5 Proteins (RFX5)

  • regulatory factor X, 5 (influences HLA class II expression) (RFX5)
  • regulatory factor X, 5 (influences HLA class II expression) (Rfx5)

Protein level used designations for Regulatory Factor X 5 Proteins (RFX5)

DNA-binding protein RFX5 , regulatory factor X 5 , DNA-binding protein Rfx5 , regulatory factor X, 5 , regulator factor X 5

GENE ID SPECIES
5993 Homo sapiens
53970 Mus musculus
483197 Canis lupus familiaris
100328902 Oryctolagus cuniculus
310659 Rattus norvegicus
100517711 Sus scrofa
539884 Bos taurus
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