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The nuclear protein encoded by RFX6 is a member of the regulatory factor X (RFX) family of transcription factors. Additionally we are shipping RFX6 Antibodies (8) and RFX6 Proteins (3) and many more products for this protein.
study reports two individuals each with compound heterozygous RFX6 nonsense mutations and an intestinal phenotype consistent with Mitchell-Riley syndrome, but with onset of diabetes in childhood rather than in the first 2 weeks of life
association of the THADA, FOXP4 (show FOXP4 ELISA Kits), GPRC6A (show GPRC6A ELISA Kits)/RFX6 and 8q24 genes with prostate cancer in Asian populations.
RFX6 controls insulin (show INS ELISA Kits) gene transcription, insulin (show INS ELISA Kits) content, and secretion by regulation of Ca(2 (show CA2 ELISA Kits)+)-channel genes.
rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus.
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 (show HOXB13 ELISA Kits) chromatin binding.
Our results provide further support for association of the C2orf43, FOXP4 (show FOXP4 ELISA Kits), GPRC6A (show GPRC6A ELISA Kits) and RFX6 genes with prostate cancer in Eastern Asian populations
RFX6 mutation is responsible for neonatal diabetes syndrome.
Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the beta-cells in addition to their development.
In early development Rfx6 plays a broad role, being essential for development of most anterior endodermal organs. At later stages however, Rfx6 function is restricted to endocrine cells.
studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans
Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing, and defective insulin (show INS ELISA Kits) secretion.
Rfx6 increases GIP (show GIP ELISA Kits) expression and content in enteroendocrine K-cells and is involved in GIP (show GIP ELISA Kits) hypersecretion in high fat diet-induced obesity.
Rfx6 is found in postmitotic islet progenitor cells in the embryo and is maintained in all developing and adult islet cell types. It is dependent on Ngn3 (show NEUROG3 ELISA Kits) and during islet cell differentiation.
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.
DNA-binding protein RFX6
, regulatory factor X domain-containing protein 1
, regulatory factor X domain containing 1
, Regulatory factor X 6