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Regulatory Factor X-Associated Ankyrin Containing Protein Proteins (RFXANK)

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. Additionally we are shipping Regulatory Factor X-Associated Ankyrin Containing Protein Antibodies (61) and Regulatory Factor X-Associated Ankyrin Containing Protein Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RFXANK 8625 O14593
RFXANK 19727 Q9Z205
Rat RFXANK RFXANK 306353  
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Top Regulatory Factor X-Associated Ankyrin Containing Protein Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RFXANK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) Interaction Partners

Human Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) interaction partners

  1. genetic, clinical, and immunologic features of 35 patients from 30 unrelated kindreds from North Africa sharing the same RFXANK founder mutation, a 26-bp deletion called I5E6-25_I5E6 + 1)

  2. Findings confirm the association between the high frequency of the combined immunodeficiency and the defect in MHC class II expression and provides strong evidence for a founder effect of the 752delG26 mutation in the North African population.

  3. Low levels of RFX-B are found in macrophages of colorectal cancer patients, partly explaining immunodeficiency in cancer.

  4. in vivo effects of mutations on the expression of the RFXANK RNA and protein

  5. ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression

  6. analysis of RFXANK domains and function

  7. RFXAP (show RFXAP Proteins) and RFXB have roles in relieving autoinhibition of RFX5 (show RFX5 Proteins)

Mouse (Murine) Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) interaction partners

  1. ANKRA, RFXANK, and CIITA are novel targets of class IIa HDACs which may deacetylases play a role in regulating MHCII expression

  2. Class II histone deacetylases (HDACs)4 and HDAC5 interact with the ankyrin repeats of ankyrin repeat, family A and RFXANK and, through association with RFXANK, repress MHC II promoter activation

Regulatory Factor X-Associated Ankyrin Containing Protein (RFXANK) Protein Profile

Protein Summary

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

Gene names and symbols associated with RFXANK

  • regulatory factor X-associated ankyrin-containing protein (RFXANK)
  • regulatory factor X-associated ankyrin-containing protein (Rfxank)
  • ANKRA1 protein
  • BLS protein
  • F14150_1 protein
  • RFX-B protein
  • Tvl1 protein

Protein level used designations for RFXANK

DNA-binding protein RFXANK , RFX-Bdelta4 , ankyrin repeat family A protein 1 , ankyrin repeat-containing regulatory factor X-associated protein , regulatory factor X subunit B , RFX-B , ankyrin repeat-containing adapter protein Tvl-1

GENE ID SPECIES
8625 Homo sapiens
19727 Mus musculus
306353 Rattus norvegicus
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