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RRAS2 encodes a member of the R-Ras subfamily of Ras-like small GTPases. Additionally we are shipping Related RAS Viral (R-Ras) Oncogene Homolog 2 Antibodies (54) and many more products for this protein.
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Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.
This article is the first study demonstrating expression of TC21 in human skin malignant tumors and suggests that TC21 is more expressed in highly aggressive skin tumors.
Suggest that TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin (show CDH1 Proteins) and N-cadherin (show CDH2 Proteins) in hepatocellular carcinoma and is associated with tumor progression and poor prognosis in HCC (show FAM126A Proteins).
RasGRF GEFs can activate TC21 in all sublocalizations except the Golgi complex. Farnesylated TC21 can be activated by RasGRF1 (show RASGRF1 Proteins) & RasGRF2 (show RASGRF2 Proteins), but geranylgeranylated TC21 is unresponsive to RasGRF2 (show RASGRF2 Proteins).
TGF-beta (show TGFB1 Proteins) and TC21 have roles in tumorigenesis
TC21 directly links antigen receptors to PI(3 (show PI3 Proteins))K-mediated survival pathways.
SIRT6 (show SIRT6 Proteins), a sirtuin (show SIRT1 Proteins) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
The RLIP76 (show RALBP1 Proteins)/R-Ras/ARNO (show CYTH2 Proteins) complex localizes to recycling endosomes.RLIP76 is a linker protein (show LAT Proteins) connecting R-Ras to ARNO (show CYTH2 Proteins).
findings reveal R-Ras2 as a critical regulator of TGF-beta (show TGFB1 Proteins) signaling in vivo.
Data indicate that RRas2(-/-) mice show no major alterations in viability, growth rates, cardiovascular parameters, or fertility.
PI3K, but not RalGDS (show RALGDS Proteins), is an important mediator of cell proliferation by TC21.
role of TC21/R-Ras2 activation in the migration of neurofibromin (show NF1 Proteins)-deficient Schwann cells
Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras (show HRAS Proteins) might favor cell migration and elongation of tubules, events that occur later in development.
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
Ras-related protein R-Ras2
, ras-like protein TC21
, ras-related protein R-Ras2
, teratocarcinoma oncogene