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Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. Additionally we are shipping Relaxin 1 Kits (34) and Relaxin 1 Proteins (5) and many more products for this protein.
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Human Polyclonal RLN1 Primary Antibody for WB - ABIN611049
Fernandes-Alnemri, Litwack, Alnemri: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. in The Journal of biological chemistry 1995
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Relaxin actions in pregnancy include increasing cervical pro-MMP-1 (show MMP1 Antibodies) and pro-MMP-3 (show MMP3 Antibodies) and decreasing TIMP-1 (show TIMP1 Antibodies), changes which soften the cervix.
We established a non-human primate model of early human pregnancy to study the effects of relaxin in vivo.
Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues.
Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation.
Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin.
Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts).
Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2 (show BCL2 Antibodies)-like1/Bax (show BAX Antibodies)-independent mechanism.
This study provides evidence for expression of RLN-RXFP1 ligand-receptor system in the boar testis, suggesting that the testes act as a source and possible target tissue of RLN.
Changes of relaxin mRNA are correlated with changes of the hormone in the CL during pregnancy, suggesting that the relaxin level is determined by the amount of mRNA available for translation.
Relaxin-producing C2C12 myoblasts displayed greater efficacy to engraft the post-ischaemic scar and to induce extracellular matrix re-modelling and angiogenesis as compared with the control cells
Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Rln enhanced synergistically BMP-2 (show BMP2 Antibodies)-induced osteoblast differentiation and bone formation.
For the first time, we bring together the systemic (ovarian) and autocrine/paracrine (intrauterine) sources of RLN, in an attempt to understand how RLN contributes to premature birth in women.
Notch (show NOTCH1 Antibodies) signaling can down-regulate TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies)-induced fibroblast-myofibroblast transition and that RLX could exert its well known anti-fibrotic action through the up-regulation of this pathway.
Recombinant human relaxin (RLX) may provide a novel therapy to manage atrial fibrillation in humans by reversing fibrosis and hypertrophy and by modulating cardiac ionic currents.
relaxin may promote the proliferation, invasion and metastasis of osteosarcoma cells by regulating the expression of MMP-9 (show MMP9 Antibodies) and facilitating ECM (show MMRN1 Antibodies) degradation.
[review] This study not only clarifies the role of relaxin in sperm, but could also open avenues of research into its use in fertility treatment.
heterozygous loss at the RLN1 locus is not a genetic factor mediating high population-wide risk for testicular germ cell tumour, but do not exclude a contribution of this aberration in some cases of cancer
Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging.
we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males.
data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2 (show RXFP2 Antibodies)
Relaxin and estrogen enhance matrix loss in the temporomandibular joint disc.
Relaxin deficiency compromises uterine artery remodeling in older pregnant females.
RLX improves impaired wound healing, enhances staining of MMP-11 (matrix metalloproteinase-11 (show MMP11 Antibodies)) and increases wound-breaking strength at day 12 in diabetic mice.
Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice
Data suggest that in proximal colon, relaxin affects constitutive nNOS (neuronal nitric oxide synthase (show NOS1 Antibodies)) and eNOS (show NOS3 Antibodies) (endothelial cell NOS (show NOS Antibodies)) but not iNOS (inducible NOS (show NOS2 Antibodies)), increasing enzyme activity and reducing muscle tone.
Relaxin knockout mice have an age-related progression of pulmonary fibrosis.
Increases in myometrial oxytocin receptor (show OXTR Antibodies) and estrogen receptor alpha (show ESR1 Antibodies) expression in late pregnant relaxin+/+ mice were attenuated in relaxin-/- mice. Probably mediated via activation of estrogen receptor-alpha (show ESR1 Antibodies).
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet.
, preprorelaxin H1
, prorelaxin H1
, prorelaxin 1
, Relaxin 1 (H1)