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The protein encoded by RIC3 promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. Additionally we are shipping RIC3 Proteins (6) and many more products for this protein.
Showing 10 out of 27 products:
Human Polyclonal RIC3 Primary Antibody for EIA, IHC (p) - ABIN954548
Walstab, Hammer, Lasitschka, Möller, Connolly, Rappold, Brüss, Bönisch, Niesler: RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. in The Journal of biological chemistry 2010
Show all 3 references for ABIN954548
In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport.
expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs
RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3.
RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use
Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR (show ACR Antibodies)-16 in Xenopus oocytes.
RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A (show HTR3A Antibodies)) receptors despite direct interactions with 5-HT3A (show HTR3A Antibodies), -C, -D, and -E subunits.
ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells
RIC-3 may play a role in 5-HT (show DDC Antibodies)(3A) receptor folding, assembly, or transport to the cell surface
hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 (show HTR3A Antibodies) expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane
Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors.
both isoforms of RIC-3 play a role in determining 5-HT3 receptor (show HTR3A Antibodies) composition.
The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, resistant to inhibitor of cholinesterase 3
, resistance to inhibitors of cholinesterase 3 homolog