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The protein encoded by RIC3 promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. Additionally we are shipping RIC3 Antibodies (27) and many more products for this protein.
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In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting 7 trafficking to dendrites and preventing axonal transport.
5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3
expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs
RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3.
RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use
Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR (show ACR Proteins)-16 in Xenopus oocytes.
RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A (show HTR3A Proteins)) receptors despite direct interactions with 5-HT3A (show HTR3A Proteins), -C, -D, and -E subunits.
ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells
RIC-3 may play a role in 5-HT (show DDC Proteins)(3A) receptor folding, assembly, or transport to the cell surface
hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 (show HTR3A Proteins) expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane
Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors.
The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, resistant to inhibitor of cholinesterase 3
, resistance to inhibitors of cholinesterase 3 homolog