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Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Additionally we are shipping RIC8A Proteins (6) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal RIC8A Primary Antibody for IP, WB - ABIN493406
Mirande: The ins and outs of tRNA transport. in EMBO reports 2007
Show all 4 references for ABIN493406
Human Polyclonal RIC8A Primary Antibody for ELISA, WB - ABIN185305
Klattenhoff, Montecino, Soto, Guzmán, Romo, García, Mellstrom, Naranjo, Hinrichs, Olate: Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. in Journal of cellular physiology 2003
Show all 3 references for ABIN185305
Data indicate that Ric-8 binds to Galpha12 (show GNA12 Antibodies)/13 subunit, Concertina (Cta (show PCYT1A Antibodies)) through an interface of conserved residues.
Ric-8, which belongs to a family of guanine nucleotide-exchange factors for Galphai, regulates cortical localization of the subunits Galphai and Gbeta13F.
both receptor-dependent and receptor-independent G-protein functions are executed at the plasma membrane and require the Ric-8 protein.
Ric-8 homologue is required for asymmetric division of both NBs (show NLRP2 Antibodies) and pl cells.Ric-8 is necessary for membrane targeting of Galphai, Pins and Gbeta13F
New studies show that targeting of G-protein subunits to membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and independent pathways.
Data suggest that Ric-8A plays essential roles during the migration of cranial neural crest (NC) cells, possibly by regulating cell adhesion and spreading.
Genetic epistasis experiments show that activator of G protein signaling (AGS-3 (show GPSM1 Antibodies)) and guanine nucleotide exchange factor (show ARHGEF12 Antibodies) RIC-8 act during food deprivation in a mutually dependent fashion to activate G protein Galpha(o (show GNAO1 Antibodies)).
Data suggest a mechanism in which RIC-8 favors generation of Galpha (show SUCLG1 Antibodies) free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division.
ric-8 (synembryn) paralysis can be rescued by neuronal G alpha(s (show GNAS Antibodies)) pathway activation.
Analysis of a ric-8 mutant suggests that it is required to maintain both the G alpha(q) vesicle priming pathway and the neuronal G alpha(s (show GNAS Antibodies)) pathway in a functional state.
RIC-8 directly modulates Galpha (show SUCLG1 Antibodies) activity and that Galpha (show SUCLG1 Antibodies)-GTP (show AK3 Antibodies) is the signaling molecule regulating spindle positioning in the early embryo
requirement toward GPA-16 is distinct from the known function of RIC-8 in enabling interaction between Galpha (show SUCLG1 Antibodies) proteins and GPR-1/2
Results suggest that RIC8A has an essential role in the development of mammalian nervous system by maintaining the integrity of pial basement membrane and modulating cell division
Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis.
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 Antibodies) alpha subunits Galphai2 (show GNAI2 Antibodies), Galphai3 (show GNAI3 Antibodies), and Galphaq (show GNAQ Antibodies).
The activity of RIC8A in neurons is essential for survival and its deficiency causes a severe neuromuscular phenotype.
Ric-8 proteins support G protein levels by serving as molecular chaperones that promote Galpha (show SUCLG1 Antibodies) subunit biosynthesis
These data indicate a dynamic interaction between GPR (show ALDH18A1 Antibodies) proteins, Galpha (show SUCLG1 Antibodies)(i1) and Ric-8A, in the cell that influences subcellular localization of the three proteins and regulates complex formation.
The results of this study revealed a novel role of Ric-8a in modulating Bergmann glia-basement membrane adhesion during foliation.
NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response
data suggest that Ric-8 proteins are molecular chaperones required for the initial association of nascent Galpha (show SUCLG1 Antibodies) subunits with cellular membranes
Ric-8A is critical for growth factor receptor-induced actin cytoskeletal reorganization
Human NCS-1 (show NCS1 Antibodies) and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas (show GNAS Antibodies) regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2.
Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha (show SUCLG1 Antibodies)(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3 (show GPSM1 Antibodies)/Galpha (show SUCLG1 Antibodies)(i/o)-GDP complex in a cellular environment.
Ric-8A co-localized with Vps34 (show PIK3C3 Antibodies) at the midbody.
The ubiquitination of Galphai2 (show GNAI2 Antibodies) and Galphaq (show GNAQ Antibodies) is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha (show SUCLG1 Antibodies) proteins; the C-terminal truncation of Galphaq (show GNAQ Antibodies) and Galphai2 (show GNAI2 Antibodies) completely abrogates their interaction with Ric-8A.
RGS14 (show RGS14 Antibodies) can form complexes with GPCRs in cells that are dependent on Galpha (show SUCLG1 Antibodies)(i/o) and these RGS14 (show RGS14 Antibodies).Galpha (show SUCLG1 Antibodies)(i1).GPCR (show NMUR1 Antibodies) complexes may be substrates for other signaling partners such as Ric-8A
Ric-8A signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle.
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
, resistance to inhibitors of cholinesterase 8 homolog A
, resistance to inhibitors of cholinesterase 8 homolog A a
, resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
, heterotrimeric G protein guanine nucleotide exchange factor Ric-8A
, resistance to inhibitors of cholinesterase 8A
, likely ortholog of mouse synembryn
, synembryn A
, Protein Ric-8A
, resistance to inhibitors of cholinesterase 8 homolog A b