anti-Retinitis Pigmentosa GTPase Regulator (RPGR) Antibodies

RPGR encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. Additionally we are shipping RPGR Kits (3) and RPGR Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RPGR 367733  
RPGR 6103 Q92834
RPGR 19893 Q9R0X5
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Top anti-RPGR Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB RPGR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RPGR Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. RPGR Antibody (C-term) western blot analysis in A549 cell line lysates (35µg/lane).This demonstrates the RPGR antibody detected the RPGR protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB RPGR Antibody (C-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RPGR antibody detected the RPGR protein (arrow). RPGR Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RPGR Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: RPGR Antibody [NBP1-84412] - Staining of human liver shows distinct cytoplasmic and membranous positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated WB Western blot analysis of RPGR expression in Y79 (A), mouse heart (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: RPGR Antibody  - Staining of human cell line RH-30 shows localization to the Golgi apparatus. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   200 μL Log in to see 7 to 9 Days
$793.83
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details

RPGR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,


, , , , ,
Mouse (Murine)


Top referenced anti-RPGR Antibodies

  1. Human Polyclonal RPGR Primary Antibody for EIA, WB - ABIN954582 : Schmid, Glaus, Cremers, Kloeckener-Gruissem, Berger, Neidhardt: Mutation- and tissue-specific alterations of RPGR transcripts. in Investigative ophthalmology & visual science 2010 (PubMed)
    Show all 3 references for 954582

  2. Human Polyclonal RPGR Primary Antibody for IHC, IHC (p) - ABIN4351043 : Shu, Zeng, Gautier, Lennon, Gakovic, Patton, Wright: Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes. in Human molecular genetics 2010 (PubMed)
    Show all 2 references for 4351043

More Antibodies against RPGR Interaction Partners

Human Retinitis Pigmentosa GTPase Regulator (RPGR) interaction partners

  1. Together with a physical interaction between RPGR and the C-terminal domain of CEP290 (show CEP290 Antibodies), our data suggest that RPGR and CEP290 (show CEP290 Antibodies) genetically interact and highlight the involvement of hypomorphic alleles of genes as potential modifiers of heterogeneous retinal ciliopathies.

  2. Studies indicate taht the majority of patients with X-linked RP have mutations in the retinitis pigmentosa GTPase regulator (RPGR) or retinitis pigmentosa 2 protein (RP2 (show NUDT19 Antibodies)) genes.

  3. We also correlated the features observed in patients with those of three Rpgr-mutant (Rpgr-ko, Rd9 (show PITPNM1 Antibodies), and Rpgr-cko) mice. In patients, there was pronounced macular disease

  4. Three mutations were identified in the ORF15 exon of RPGR. No RP2 (show NUDT19 Antibodies) mutations were found among the examined families. Mutation screening of RP patients is essential to understand the mechanism behind this disease and develop treatments

  5. Profound visual loss occurred by the second decade of life with progression to near no light perception by age 60 in this kindred of X-linked RP associated with the RPGR genotype.

  6. The regulator of chromosome condensation 1 (show RCC1 Antibodies)-like (show RCBTB2 Antibodies) domain of RPGR was conserved in vertebrates and invertebrates, but RPGR(ORF15) was unique to vertebrates.

  7. Coverage-based analysis indicated that the RPGR open reading frame (ORF)15 was located in an uncovered or low-depth region. Through additional screening of ORF15, we identified pathogenic mutations in 14% (7/50) of patients.

  8. X-linked retinitis pigmentosa caused by mutations in the RPGR gene is a severe and early onset form of retinal degeneration. [review]

  9. Severe retinal degeneration is found in a Czech family women with a c.2543del mutation in ORF15 of the RPGR gene.

  10. RPGR mutations associated with X-linked retinitis pigmentosa.

Mouse (Murine) Retinitis Pigmentosa GTPase Regulator (RPGR) interaction partners

  1. Together with a physical interaction between RPGR and the C-terminal domain of CEP290 (show CEP290 Antibodies), our data suggest that RPGR and CEP290 (show CEP290 Antibodies) genetically interact and highlight the involvement of hypomorphic alleles of genes as potential modifiers of heterogeneous retinal ciliopathies.

  2. We also correlated the features observed in patients with those of three Rpgr-mutant (Rpgr-ko, Rd9 (show PITPNM1 Antibodies), and Rpgr-cko) mice. In patients, there was pronounced macular disease

  3. The discordant effect of the loss of RPGR on rod-dominant or cone-only rodent retinas is shown.

  4. study uncovers the pathogenic mechanism whereby absence of RPGR(ORF15) glutamylation leads to retinal pathology in patients with TTLL5 (show TTLL5 Antibodies) gene mutations and connects these two genes into a common disease pathway.

  5. Given a frequent occurrence of RPGR mutations in severe photoreceptor degeneration due to ciliary disorders, our results provide insights into pathways resulting in altered mature cilia function in ciliopathies.

  6. Data shsow that Rpgr ORF15 transcripts, but not protein, were detected in retinas from Rd9 (show PITPNM1 Antibodies)/Y male mice that exhibited retinal pathology.

  7. Misexpression of Rpgr(ex1 (show FRMD6 Antibodies)-19) causes retinal degeneration that is considerably more severe than that caused by Rpgr knockout but photoreceptors tolerate overexpression of Rpgr(ORF15) without evidence of degeneration.

  8. RPGR localizes to the podocytes in the glomerulus as well as to primary cilia in parietal epithelium and tubules

  9. RPGR and RPGRIP (show RPGRIP1 Antibodies) isoforms are distributed and co-localized at restricted foci throughout the outer segments of human and bovine, but not mice rod photoreceptors.

  10. Certain truncated forms of RPGR can behave as a dominant, gain-of-function mutant.

RPGR Antigen Profile

Protein Summary

This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined.

Gene names and symbols associated with RPGR

  • retinitis pigmentosa GTPase regulator (Rpgr) antibody
  • retinitis pigmentosa GTPase regulator (RPGR) antibody
  • retinitis pigmentosa GTPase regulator (rpgr) antibody
  • retinitis pigmentosa GTPase regulator (Bm1_19935) antibody
  • retinitis pigmentosa GTPase regulator (NAEGRDRAFT_80250) antibody
  • COD1 antibody
  • CORDX1 antibody
  • CRD antibody
  • orf15 antibody
  • PCDX antibody
  • RP3 antibody
  • Rp3h antibody
  • RP15 antibody
  • XLRP3 antibody
  • xrpgr antibody

Protein level used designations for RPGR

X-linked retinitis pigmentosa GTPase regulator , retinitis pigmentosa GTPase regulator , RPGR 1-19 isoform , X-linked retinitis pigmentosa GTPase regulator-like , retinitis pigmentosa 15 , retinitis pigmentosa 3 GTPase regulator , mRpgr , retinitis pigmentosa GTP-ase regulator RPGR

GENE ID SPECIES
367733 Rattus norvegicus
418578 Gallus gallus
513263 Bos taurus
554332 Ovis aries
698053 Macaca mulatta
733454 Xenopus (Silurana) tropicalis
734172 Xenopus laevis
6098892 Brugia malayi
8852870 Naegleria gruberi strain NEG-M
100170141 Sus scrofa
100389535 Callithrix jacchus
6103 Homo sapiens
19893 Mus musculus
403726 Canis lupus familiaris
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