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RBBP5 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. Additionally we are shipping Retinoblastoma Binding Protein 5 Antibodies (60) and Retinoblastoma Binding Protein 5 Proteins (4) and many more products for this protein.
This study demonstrated that RBQ3 might play an important role in glioma, and RBQ3 inhibitors might be novel anti-tumor agents.
The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1, DBC-1, and EMSY.
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L heterodimer.
Data indicate that MLL1 methylates Ash2L in the absence of histone H3 (show HIST3H3 ELISA Kits), but only when assembled within a complex with WDR5 (show WDR5 ELISA Kits) and RbBP5.
structural and biochemical analyses reveal a basic surface on Ash2L as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation
Results show that Depletion of CHD8 (show CHD8 ELISA Kits) enhances HOXA2 (show HOXA2 ELISA Kits) expression and a loss of the WDR5 (show WDR5 ELISA Kits)/Ash2L/RbBP5 subcomplex.
analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1
a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2 (show DNMT1 ELISA Kits)) enzyme methylation rates
Characterization of a novel WDR5 (show WDR5 ELISA Kits)-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (show HIST3H3 ELISA Kits) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
retinoblastoma binding protein 5
, retinoblastoma-binding protein 5-like
, SWD1, Set1c WD40 repeat protein, homolog
, retinoblastoma-binding protein 5
, retinoblastoma-binding protein RBQ-3