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Retinoblastoma Binding Protein 5 Proteins (RBBP5)

RBBP5 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. Additionally we are shipping Retinoblastoma Binding Protein 5 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RBBP5 5929 Q15291
RBBP5 213464 Q8BX09
Rat RBBP5 RBBP5 304794  
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Top Retinoblastoma Binding Protein 5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

RBBP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Retinoblastoma Binding Protein 5 (RBBP5) Interaction Partners

Human Retinoblastoma Binding Protein 5 (RBBP5) interaction partners

  1. This study demonstrated that RBQ3 might play an important role in glioma, and RBQ3 inhibitors might be novel anti-tumor agents.

  2. The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L (show ASH2L Proteins), RbBP5, WDR5 (show WDR5 Proteins), HCF-1 (show HCFC1 Proteins), DBC-1 (show DBC1 Proteins), and EMSY (show C11orf30 Proteins).

  3. Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L (show ASH2L Proteins) heterodimer.

  4. Data indicate that MLL1 methylates Ash2L (show ASH2L Proteins) in the absence of histone H3 (show HIST3H3 Proteins), but only when assembled within a complex with WDR5 (show WDR5 Proteins) and RbBP5.

  5. structural and biochemical analyses reveal a basic surface on Ash2L (show ASH2L Proteins) as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation

  6. Results show that Depletion of CHD8 enhances HOXA2 (show HOXA2 Proteins) expression and a loss of the WDR5 (show WDR5 Proteins)/Ash2L (show ASH2L Proteins)/RbBP5 subcomplex.

  7. analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1

Mouse (Murine) Retinoblastoma Binding Protein 5 (RBBP5) interaction partners

  1. a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2 (show DNMT1 Proteins)) enzyme methylation rates

  2. Characterization of a novel WDR5 (show WDR5 Proteins)-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Proteins) lysine 4 by mixed lineage leukemia protein-1.

Retinoblastoma Binding Protein 5 (RBBP5) Protein Profile

Protein Summary

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with RBBP5

  • retinoblastoma binding protein 5 (RBBP5)
  • retinoblastoma binding protein 5 (rbbp5)
  • retinoblastoma binding protein 5 (LOC100356995)
  • retinoblastoma binding protein 5 (Rbbp5)
  • 4933411J24Rik protein
  • C330016J05 protein
  • DKFZp469C191 protein
  • MGC56078 protein
  • MGC80141 protein
  • MGC97793 protein
  • RBBP5 protein
  • RBQ3 protein
  • SWD1 protein
  • zgc:56078 protein
  • zgc:85864 protein

Protein level used designations for RBBP5

retinoblastoma binding protein 5 , retinoblastoma-binding protein 5-like , RBBP-5 , SWD1, Set1c WD40 repeat protein, homolog , retinoblastoma-binding protein 5 , retinoblastoma-binding protein RBQ-3

GENE ID SPECIES
100054708 Equus caballus
393215 Danio rerio
446510 Xenopus laevis
457665 Pan troglodytes
595072 Xenopus (Silurana) tropicalis
100173341 Pongo abelii
100356995 Oryctolagus cuniculus
100470847 Ailuropoda melanoleuca
100513301 Sus scrofa
100544888 Meleagris gallopavo
100566805 Anolis carolinensis
100597470 Nomascus leucogenys
5929 Homo sapiens
488568 Canis lupus familiaris
510455 Bos taurus
213464 Mus musculus
304794 Rattus norvegicus
419826 Gallus gallus
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