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RBBP5 encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. Additionally we are shipping Retinoblastoma Binding Protein 5 Antibodies (56) and many more products for this protein.
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The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L (show ASH2L Proteins), RbBP5, WDR5 (show WDR5 Proteins), HCF-1 (show HCFC1 Proteins), DBC-1 (show DBC1 Proteins), and EMSY (show C11orf30 Proteins).
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L (show ASH2L Proteins) heterodimer.
Data indicate that MLL1 methylates Ash2L (show ASH2L Proteins) in the absence of histone H3 (show HIST3H3 Proteins), but only when assembled within a complex with WDR5 (show WDR5 Proteins) and RbBP5.
structural and biochemical analyses reveal a basic surface on Ash2L (show ASH2L Proteins) as the RbBP5-binding interface, and this interface is crucial for both RbBP5 binding and MLL1 methyltransferase activity regulation
Results show that Depletion of CHD8 enhances HOXA2 (show HOXA2 Proteins) expression and a loss of the WDR5 (show WDR5 Proteins)/Ash2L (show ASH2L Proteins)/RbBP5 subcomplex.
analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1
a phosphorylation switch on RbBP5 stimulates WRAD complex formation and significantly increases KMT2 (lysine [K] methyltransferase 2 (show DNMT1 Proteins)) enzyme methylation rates
Characterization of a novel WDR5 (show WDR5 Proteins)-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Proteins) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
retinoblastoma binding protein 5
, retinoblastoma-binding protein 5-like
, SWD1, Set1c WD40 repeat protein, homolog
, retinoblastoma-binding protein 5
, retinoblastoma-binding protein RBQ-3