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RAET1E belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. Additionally we are shipping Retinoic Acid Early Transcript 1E Antibodies (101) and Retinoic Acid Early Transcript 1E Kits (2) and many more products for this protein.
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Human RAET1E Protein expressed in Escherichia coli (E. coli) - ABIN1098707
Antoun, Jobson, Cook, OCallaghan, Moss, Briggs: Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. in Human immunology 2010
Show all 2 references for ABIN1098707
5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding
RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null.
Patients whose tumors had high expression of RAET1E, ULBP1 and ULBP3 surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands
Binds the activating receptor NKG2D (show KLRK1 Proteins).
immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D (show KLRK1 Proteins)-mediated NK cell cytotoxicity to tumors
All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D (show KLRK1 Proteins) receptor in vitro
data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D (show KLRK1 Proteins) and may play a key role in immune surveillance of tumor development and clearance of viral infection
CD4 (show CD4 Proteins)(+) NKG2D (show KLRK1 Proteins)(+) T cells induce NKG2D (show KLRK1 Proteins) down-regulation in natural killer cells in CD86 (show CD86 Proteins)-RAE-1epsilon transgenic mice.
Reveal Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene.
Raet1e genes are directly transcriptionally activated by E2F (show E2F1 Proteins) family transcription factors, which play a central role in regulating cell cycle entry.
RAE1 (show RAE1 Proteins) expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NKG2D ligand 4
, RAE-1-like transcript 4
, lymphocyte effector toxicity activation ligand
, Rae-1 epsilon
, retinoic acid early-inducible protein 1-epsilon