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RAET1E belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. Additionally we are shipping Retinoic Acid Early Transcript 1E Proteins (9) and Retinoic Acid Early Transcript 1E Kits (2) and many more products for this protein.
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Human Polyclonal RAET1E Primary Antibody for WB - ABIN1881724
Radosavljevic, Cuillerier, Wilson, Clément, Wicker, Gilfillan, Beck, Trowsdale, Bahram: A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. in Genomics 2002
Show all 7 references for ABIN1881724
5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding
RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null.
Patients whose tumors had high expression of RAET1E, ULBP1 (show ULBP1 Antibodies) and ULBP3 (show ULBP3 Antibodies) surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands
Binds the activating receptor NKG2D (show KLRK1 Antibodies).
immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D (show KLRK1 Antibodies)-mediated NK cell cytotoxicity to tumors
All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D (show KLRK1 Antibodies) receptor in vitro
data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D (show KLRK1 Antibodies) and may play a key role in immune surveillance of tumor development and clearance of viral infection
CD4 (show CD4 Antibodies)(+) NKG2D (show KLRK1 Antibodies)(+) T cells induce NKG2D (show KLRK1 Antibodies) down-regulation in natural killer cells in CD86 (show CD86 Antibodies)-RAE-1epsilon transgenic mice.
Reveal Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene.
Raet1e genes are directly transcriptionally activated by E2F (show E2F1 Antibodies) family transcription factors, which play a central role in regulating cell cycle entry.
RAE1 (show RAE1 Antibodies) expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NKG2D ligand 4
, RAE-1-like transcript 4
, lymphocyte effector toxicity activation ligand
, Rae-1 epsilon
, retinoic acid early-inducible protein 1-epsilon