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Members of the RAET1 family, such as RAET1G, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. Additionally we are shipping Retinoic Acid Early Transcript 1G Kits (24) and Retinoic Acid Early Transcript 1G Antibodies (4) and many more products for this protein.
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Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2 (show ULBP2 Proteins)/5/6 and chemoattract NK cells.
RAET1G is regulated post-translationally to produce a GPI (show GNPDA1 Proteins)-anchored isoform
Binds the activating receptor NKG2D (show KLRK1 Proteins) and the the human cytomegalovirus protein UL16.
the expression patterns of ULBP5RAET1G are very similar to the well-characterised NKG2D (show KLRK1 Proteins) ligand, MICA (show MICA Proteins). However the two isoforms of ULBP5/RAET1G have very different cellular localisations that are likely to reflect unique functionality.
RAET1G, like ULBP2, appears broadly expressed, but exhibits a lower apparent avidity for NKG2D due to a mutation in the center of the MHC-like fold.
Members of the RAET1 family, such as RAET1G, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E (MIM 609243) and RAET1G differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1\; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. (Radosavljevic et al., 2002
retinoic acid early transcript 1G
, retinoic acid early transcript 1G protein
, retinoic acid early transcript 1G pseudogene
, MHC Class I-like gene family A2