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RDH10 encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Additionally we are shipping Retinol Dehydrogenase 10 (All-Trans) Antibodies (49) and many more products for this protein.
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Insulin (show INS Proteins) inhibits retinoic acid biosynthesis through inhibition of FoxO1 (show FOXO1 Proteins)-induced Rdh10 gene expression.
Data indicate that retinaldehyde reductase (DHRS3 (show DHRS3 Proteins)) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10.
all three proteins (RDH10, RALDH2 (show ALDH1A2 Proteins), and CRABP2 (show CRABP2 Proteins)) appeared to be required for ATRA production induced by activation of PPARgamma (show PPARG Proteins)
Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.
CYP4Z1 (show CYP4Z1 Proteins), KIR (show GEM Proteins) and RDH10 could play a role in non-small-cell lung cancer progression
organization of the gene includes a unique transcriptional start site, a coding region with six translated exons and a 3' UTR containing at least two used polyadenylation sites.
Forced over-expression of the RDH10 gene causes growth arrest of HepG2 cells and could be a possible curative strategy for hepatocellular carcinoma.
dual physiological role for RDH10: in the biosynthesis of 11-cis (show CISH Proteins)-retinaldehyde for vision as well as the biosynthesis of all-trans-retinoic acid for differentiation and development
wild-type RDH10 catalysed both oxidation of all-trans-retinol and reduction of all-trans-retinal in a cofactor-dependent manner In vitro, however, oxidation is the favoured reaction catalysed by RDH10
RDH10 acts in cooperation with other RDH isoforms to produce the 11-cis (show CISH Proteins)-retinal chromophore needed for vision.
Rdh10-/- embryos demonstrate that RA controls hindbrain but not early forebrain patterning, while studies on retinaldehyde-rescued Rdh10-/- embryos show that meningeal RA synthesis is unnecessary to stimulate forebrain cortical expansion.
Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.
retinol dehydrogenase (show ADH7 Proteins) Rdh10 localizes to lipid droplets during acyl ester biosynthesis
RDH10-mediated oxidation of retinol plays as important a role in the control and regulation of retinoic acid production during embryogenesis as does the subsequent RALDH-mediated reaction.
identified a missense mutation in the Rdh10 gene (Rdh10(m366Asp) ) using an N-ethyl-N-nitrosourea-induced forward genetic screen that result in reduced RA levels and signaling during embryonic development
Retinol dehydrogenase 10 is involved in embryonic patterning and its loss of function can be rescued by maternal retinaldehyde treatment.
Using protein modeling, enzymatic assays, and mutant embryos, we determined that RDH10(trex) mutant protein lacks the ability to oxidize retinol to retinal, resulting in insufficient retinoic acid signaling.
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
retinol dehydrogenase 10
, retinol dehydrogenase 10-B
, retinol dehydrogenase 10 (all-trans)
, retinol dehydrogenase 10-like
, short chain dehydrogenase/reductase family 16C, member 4