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anti-Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Antibodies

Exhibits an oxidoreductive catalytic activity towards retinoids. Additionally we are shipping RDH12 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
RDH12 314264  
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Top anti-RDH12 Antibodies at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RDH12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Fruit Fly Rabbit Un-conjugated WB WB Suggested Anti-RDH12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged RDH12 is 0.3 ng/ml as a capture antibody. Immunofluorescence of monoclonal antibody to RDH12 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB RDH12 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.Lane 1: RDH12 transfected lysate(35.10 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated WB Western Blot analysis of RDH12 expression in transfected 293T cell line by RDH12 MaxPab polyclonal antibody.Lane 1: RDH12 transfected lysate(34.76 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 11 to 16 Days
$553.14
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 11 to 16 Days
$590.86
Details

RDH12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human
,
,
Rat (Rattus)


Top referenced anti-RDH12 Antibodies

  1. Chicken Polyclonal RDH12 Primary Antibody for WB - ABIN2785176 : Sun, Gerth, Maeda, Lodowski, Van Der Kraak, Saperstein, Héon, Palczewski: Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. in Vision research 2007 (PubMed)

More Antibodies against RDH12 Interaction Partners

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5 (show RDH5 Antibodies), Rdh8 (show HSD17B6 Antibodies), or Rdh11 (show RDH11 Antibodies), suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced (show SQSTM1 Antibodies) by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 (show RDH11 Antibodies) suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy (show MERTK Antibodies). All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  2. Mutations in the AIPL1 (show AIPL1 Antibodies) and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  3. Here we demonstrate that microtubule-associated protein 1 light chain 3A (show MAP1LC3A Antibodies) (LC3A (show MAP1LC3A Antibodies)), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  4. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy (show MERTK Antibodies) had a progressive decrease of their vision with the formation of a posterior staphyloma.

  5. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  6. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy (show MERTK Antibodies).

  7. LCA (show CLTA Antibodies) has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  8. The retina RDH12 reduces 4-HNE (show ELANE Antibodies) to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

  9. Results suggest that the accelerated degradation of RDH12 mutants by the ubiquitin-proteasome system contributes to the pathophysiology and phenotypic variability associated with mutations in the RDH12 gene.

  10. Our studies show that RDH12 is associated with retinal dystrophy (show MERTK Antibodies) and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells.

RDH12 Antigen Profile

Protein Summary

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Gene names and symbols associated with RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12) antibody
  • retinol dehydrogenase 12 (all-trans and 9-cis) (rdh12) antibody
  • retinol dehydrogenase 12 (MAV_1968) antibody
  • retinol dehydrogenase 12 (CC1G_02720) antibody
  • Retinol dehydrogenase 12 (Bm1_36660) antibody
  • retinol dehydrogenase 12 (PTRG_03574) antibody
  • retinol dehydrogenase 12 (PTRG_05326) antibody
  • retinol dehydrogenase 12 (PTRG_08067) antibody
  • retinol dehydrogenase 12 (LOC100282710) antibody
  • retinol dehydrogenase 12 (LOC100285880) antibody
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (LOC100226769) antibody
  • retinol dehydrogenase 12 (Rdh12) antibody
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12) antibody
  • A930033N07Rik antibody
  • DSSDR2 antibody
  • LCA3 antibody
  • LCA13 antibody
  • RP53 antibody
  • SDR7C2 antibody
  • wu:fj43a10 antibody
  • zgc:92430 antibody

Protein level used designations for RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPECIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
Selected quality suppliers for anti-RDH12 (RDH12) Antibodies
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