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Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) Proteins (RDH12)

Exhibits an oxidoreductive catalytic activity towards retinoids. Additionally we are shipping RDH12 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RDH12 77974 Q8BYK4
RDH12 145226 Q96NR8
Rat RDH12 RDH12 314264  
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Top RDH12 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,847.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

RDH12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
, ,

Top referenced RDH12 Proteins

  1. Human RDH12 Protein expressed in Escherichia coli (E. coli) - ABIN668007 : Keller, Adamski: RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. in The Journal of steroid biochemistry and molecular biology 2007 (PubMed)
    Show all 2 references for ABIN668007

More Proteins for Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) Interaction Partners

Mouse (Murine) Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. RDH12 in inner segments can protect vital cell organelles against aldehyde toxicity caused by an intracellular leak of all-trans-retinal, as well as other aldehydes originating both inside and outside the cell.

  2. RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye.

  3. The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5 (show RDH5 Proteins), Rdh8 (show HSD17B6 Proteins), or Rdh11 (show RDH11 Proteins), suggest that the activity of any one isoform is not rate limiting in the visual response.

  4. Oxidative stress induced (show SQSTM1 Proteins) by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 (show RDH11 Proteins) suggested a housekeeping function for this enzyme.

  5. a critical function of RDH12 is the reduction of all-trans-retinal that exceeds the reductive capacity of the photoreceptor outer segments

Human Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis) (RDH12) interaction partners

  1. We report 4 children from 3 consanguineous families with bilateral elevation deficiency in the context of retinal dystrophy (show MERTK Proteins). All were found to harbor recessive mutations in retinal dehydrogenase 12 (RDH12).

  2. Mutations in the AIPL1 (show AIPL1 Proteins) and RDH12 genes associated with leber congenital amaurosis in two Turkish families.

  3. Here we demonstrate that microtubule-associated protein 1 light chain 3A (show MAP1LC3A Proteins) (LC3A (show MAP1LC3A Proteins)), a marker of autophagy, is related to hypoxia and poor prognosis in clear cell ovarian cancer.

  4. The three patients with Leber congenital amaurosis/early-onset retinal dystrophy (show MERTK Proteins) had a progressive decrease of their vision with the formation of a posterior staphyloma.

  5. Two novel missense mutations in the RDH12 gene are associated with retinitis pigmentosa.

  6. Seventeen novel mutations in the RDH12 gene were identified that accounted for approximately 7% of disease in a cohort of patients diagnosed with Leber congenital amaurosis and early-onset retinal dystrophy (show MERTK Proteins).

  7. LCA (show CLTA Proteins) has been associated with sequence variations of 14 different genes; in approximately 30% of all cases pathogenic mutations remain to be determined.

  8. The retina RDH12 reduces 4-HNE (show ELANE Proteins) to a nontoxic alcohol, protecting cellular macromolecules against oxidative modification and protecting photoreceptors from light-induced apoptosis.

  9. Results suggest that the accelerated degradation of RDH12 mutants by the ubiquitin-proteasome system contributes to the pathophysiology and phenotypic variability associated with mutations in the RDH12 gene.

  10. Our studies show that RDH12 is associated with retinal dystrophy (show MERTK Proteins) and encodes an enzyme with a unique, nonredundant role in the photoreceptor cells.

RDH12 Protein Profile

Protein Summary

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity).

Gene names and symbols associated with RDH12

  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (RDH12)
  • retinol dehydrogenase 12 (all-trans and 9-cis) (rdh12)
  • retinol dehydrogenase 12 (MAV_1968)
  • retinol dehydrogenase 12 (CC1G_02720)
  • Retinol dehydrogenase 12 (Bm1_36660)
  • retinol dehydrogenase 12 (PTRG_03574)
  • retinol dehydrogenase 12 (PTRG_05326)
  • retinol dehydrogenase 12 (PTRG_08067)
  • retinol dehydrogenase 12 (LOC100282710)
  • retinol dehydrogenase 12 (LOC100285880)
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (LOC100226769)
  • retinol dehydrogenase 12 (Rdh12)
  • retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (Rdh12)
  • A930033N07Rik protein
  • DSSDR2 protein
  • LCA3 protein
  • LCA13 protein
  • RP53 protein
  • SDR7C2 protein
  • wu:fj43a10 protein
  • zgc:92430 protein

Protein level used designations for RDH12

retinol dehydrogenase 12 (all-trans and 9-cis) , retinol dehydrogenase 12 , Retinol dehydrogenase 12 , retinol dehydrogenase 12 (all-trans/9-cis/11-cis) , all-trans and 9-cis retinol dehydrogenase , retinol dehydrogenase 12, all-trans and 9-cis , short chain dehydrogenase/reductase family 7C, member 2 , double substrate specificity short chain dehydrogenase/reductase 2 , double substrate specificity short-chain dehydrogenase/reductase 2 , double substrate-specificity short chain dehydrogenase/reductase 2

GENE ID SPECIES
423274 Gallus gallus
436597 Danio rerio
4528332 Mycobacterium avium 104
6016890 Coprinopsis cinerea okayama7130
6102217 Brugia malayi
6341805 Pyrenophora tritici-repentis Pt-1C-BFP
6343577 Pyrenophora tritici-repentis Pt-1C-BFP
6346345 Pyrenophora tritici-repentis Pt-1C-BFP
100282710 Zea mays
100285880 Zea mays
490744 Canis lupus familiaris
711438 Macaca mulatta
100226769 Taeniopygia guttata
77974 Mus musculus
145226 Homo sapiens
314264 Rattus norvegicus
369021 Bos taurus
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