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Retinoschisin 1 Proteins (RS1)

RS1 encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. Additionally we are shipping Retinoschisin 1 Antibodies (8) and Retinoschisin 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RS1 6247 O15537
Mouse RS1 RS1 20147 Q9Z1L4
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Top Retinoschisin 1 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Takifugu rubripes His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

RS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Takifugu rubripes

More Proteins for Retinoschisin 1 (RS1) Interaction Partners

Pig (Porcine) Retinoschisin 1 (RS1) interaction partners

Human Retinoschisin 1 (RS1) interaction partners

  1. A novel RS1 (304C > T) mutation in a Taiwanese family with X-linked retinoschisis.

  2. We identified a novel causative mutation of RS1 in a Chinese family with X-linked juvenile retinoschisis.

  3. the disease and p.Arg197Cys mutation of RS1 gene was identified

  4. Sequencing of the RS1 gene identified 16 mutations, nine of which were novel.

  5. Severe RS1 missense changes were associated with a lower ERG b (show ERG Proteins)/a ratio than were mild changes in X-linked retinoschisis suggesting the effect of the mutations on protein structure influenced the retinal dysfunction.

  6. Two novel exonic deletions within the RS1 gene locus, are reported.

  7. There is profound phenotypic variability in patients with XLRS. Nonsense, splice-site, or frame-shifting mutations in RS1 consistently caused electronegative bright-flash ERG (show ERG Proteins), delayed flicker response, and abnormal PERG

  8. Four novel RS1 gene mutations have been described in male Polish patients with X-linked juvenile retinoschisis.

  9. aggregation propensity in the RS1 C110Y mutant is dependent upon the formation of suitable aggregating substrates for propagation of aggregation and not directly related to or determined by overall structural instability

  10. Ten hemizygous mutations in RS1 were detected in patients from 14 of the 20 families with retinoschisis.

Mouse (Murine) Retinoschisin 1 (RS1) interaction partners

  1. Changes in Rs1-knockout mice were associated with age related alterations in photoreceptor morphology and transcription factor expression that suggest delayed photoreceptor maturation.

  2. Time line analysis after short-term treatment with dorzolamide failed to show short-, intermediate-, or long-term evidence of structural improvement in Rs1h(-/y) mice.

  3. The results of this study demonstrated that loss of Rs1 gene function has a significant impact on the expression of photoreceptor transcription factor network genes, and morphological and functional defects in young (P21) Rs1-KO mice.

  4. RS1 is needed for preservation of synaptic structures but not synaptogenesis in retinoschisis model.

  5. Data suggest that a CpG island enhancer and two CBRs may act in a combinatorial fashion to fine-tune RS1 transcript levels in the retina.

  6. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 (show ATP1A3 Proteins) and ATP1B2 (show ATP1B2 Proteins).

  7. Upon Rs1 adsorption, phosphatidylserine and phosphatidylserine-containing mixed lipid bilayers underwent fast and extensive reorganization.

  8. Inactivation of Rs1h suggests a role of retinoschisin in retinal cell layer organization and synaptic structure

  9. After synthesis and secretion by the photoreceptors, retinoschisin [Xlrs1] reaches the surface of retinal cells and mediates interactions/adhesion between photoreceptor, bipolar, and Muller cells

  10. Mimics structural features of human X-linked juvenile retinoschisis. Knockout results in electronegative ERG (show ERG Proteins) waveform characteristic of human retinoschisis and implicates synaptic transmission deficit in the absence of retinoschisin protein.

Retinoschisin 1 (RS1) Protein Profile

Protein Summary

This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

Gene names and symbols associated with Retinoschisin 1 Proteins (RS1)

  • retinoschisin 1 (RS1)
  • retinoschisin 1 (rs1)
  • retinoschisis (X-linked, juvenile) 1 (human) (Rs1)
  • RS protein
  • Rs1h protein
  • tmgc1 protein
  • Xlrs1 protein

Protein level used designations for Retinoschisin 1 Proteins (RS1)

retinoschisis (X-linked, juvenile) 1 , retinoschisin 1 , retinoschisin , retinoschisin-like , X-linked juvenile retinoschisis protein , X-linked juvenile retinoschisis protein homolog , retinoschisis 1 homolog

491762 Canis lupus familiaris
615193 Bos taurus
748866 Pan troglodytes
779332 Xenopus laevis
100124900 Xenopus (Silurana) tropicalis
100126075 Oryctolagus cuniculus
100127441 Sus scrofa
100423325 Macaca mulatta
6247 Homo sapiens
20147 Mus musculus
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