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RTL1 is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. Additionally we are shipping RTL1 Antibodies (23) and and many more products for this protein.
In addition to identifying Rtl1 as a novel driver of HCC (show FAM126A ELISA Kits), our study represents one of the first direct in vivo demonstrations of a role for such a co-opted genetic element in promoting carcinogenesis.
RTL1, a paternally expressed gene in a cluster of imprinted genes on chromosome 14q32.2, is associated with upd (show UROD ELISA Kits)(14)pat-like and upd (show UROD ELISA Kits)(14)mat-like phenotypes.
miR-127 is an essential regulator of Rtl1, mediated by a trans-homologue interaction between reciprocally imprinted genes on the maternally and paternally inherited chromosomes
Rtl1, an imprinted gene with preferential expression from the paternal allele, is essential for maintenance of the fetal capillaries.
Despite the coordinate down-regulation of Dlk1 (show DLK1 ELISA Kits) and Rtl1 mRNA levels, Rtl1 over-expression did not affect the time course of adipogenesis or Dlk1 (show DLK1 ELISA Kits) expression
These data support a role for mir-127 and mir-136 in the epigenetic reprogramming of the Rtl1 imprinting process.
This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries.
mammalian retrotransposon derived protein 1
, paternally expressed gene 11 protein
, retrotransposon-derived protein PEG11
, retrotransposon-like protein 1
, paternally expressed gene 11 protein homolog