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anti-Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) Antibodies

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Additionally we are shipping RHBDF2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RHBDF2 79651 Q6PJF5
RHBDF2 217344 Q80WQ6
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Top anti-RHBDF2 Antibodies at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB RHBDF2 Antibody (N-term) (ABIN657511) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the RHBDF2 antibody detected the RHBDF2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$532.71
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit FITC IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL Log in to see 16 Days
$710.29
Details

RHBDF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,


, , , , ,
Mouse (Murine)


More Antibodies against RHBDF2 Interaction Partners

Human Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. results explain how loss of the amino terminus in iRhom1 (show RHBDF1 Antibodies) and iRhom2 impairs TNF (show TNF Antibodies) signaling, despite enhancing ADAM17 (show ADAM17 Antibodies) activity

  2. Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (show ADAM17 Antibodies) in epidermal keratinocytes.

  3. Our analyses suggest that these DNA methylation (show HELLS Antibodies) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.

  4. RHBDF2 and CYGB (show CYGB Antibodies) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.

  5. The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.

Mouse (Murine) Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. iRhom2 is required for the maturation of TACE (show ADAM17 Antibodies) and hair follicle differentiation.

  2. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 Antibodies)-dependent EGFR (show EGFR Antibodies) signaling

  3. Rhbdf2 mutations increase its protein stability and drive EGFR (show EGFR Antibodies) hyperactivation through enhanced secretion of amphiregulin (show AREG Antibodies).

  4. findings uncover functions for iRhom2 in the regulation of EGFR (show EGFR Antibodies) signaling and in controlling the activation and substrate selectivity of ADAM17 (show ADAM17 Antibodies)-dependent shedding events

  5. mice lacking Rhbdf2 were protected from K/BxN inflammatory arthritis to the same extent as mice lacking TACE (show ADAM17 Antibodies) in myeloid cells or Tnfa (show TNF Antibodies)-deficient mice

  6. These results establish a specific role for iRhom2 in the secretion of TNFalpha (show TNF Antibodies).

  7. iRhom2 is required for TNF (show TNF Antibodies) release; iRhom2 binds TACE (show ADAM17 Antibodies) and promotes its exit from the ER; failure of TACE (show ADAM17 Antibodies) to exit the ER in the absence of iRhom2 prevents the furin (show FURIN Antibodies)-mediated maturation and trafficking of TACE (show ADAM17 Antibodies) to the cell surface, the site of TNF (show TNF Antibodies) cleavage

  8. study reports iRhom2 interacted with TACE (show ADAM17 Antibodies) and regulated TNFalpha (show TNF Antibodies) shedding; iRhom2 was critical for TACE (show ADAM17 Antibodies) maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity

RHBDF2 Antigen Profile

Protein Summary

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).

Gene names and symbols associated with RHBDF2

  • rhomboid 5 homolog 2 (Drosophila) (RHBDF2) antibody
  • rhomboid 5 homolog 2 (Drosophila) (Rhbdf2) antibody
  • 4732465I17Rik antibody
  • RHBDL5 antibody
  • Rhbdl6 antibody
  • TOC antibody

Protein level used designations for RHBDF2

iRhom2 , inactive rhomboid protein 2 , rhomboid family member 2 , rhomboid veinlet-like protein 5 , rhomboid veinlet-like protein 6 , rhomboid, veinlet-like 6 , rhomboid-like protein 6 , rhomboid-related protein , Rhomboid family member 2 , rhomboid veinlet-like 6

GENE ID SPECIES
79651 Homo sapiens
217344 Mus musculus
483332 Canis lupus familiaris
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