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Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) ELISA Kits

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Additionally we are shipping RHBDF2 Antibodies (20) and RHBDF2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human RHBDF2 RHBDF2 79651 Q6PJF5
Anti-Mouse RHBDF2 RHBDF2 217344 Q80WQ6
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More ELISA Kits for RHBDF2 Interaction Partners

Human Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. results explain how loss of the amino terminus in iRhom1 (show RHBDF1 ELISA Kits) and iRhom2 impairs TNF (show TNF ELISA Kits) signaling, despite enhancing ADAM17 (show ADAM17 ELISA Kits) activity

  2. Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (show ADAM17 ELISA Kits) in epidermal keratinocytes.

  3. Our analyses suggest that these DNA methylation (show HELLS ELISA Kits) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.

  4. RHBDF2 and CYGB (show CYGB ELISA Kits) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.

  5. The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.

Mouse (Murine) Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. iRhom2 is required for the maturation of TACE (show ADAM17 ELISA Kits) and hair follicle differentiation.

  2. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 ELISA Kits)-dependent EGFR (show EGFR ELISA Kits) signaling

  3. Rhbdf2 mutations increase its protein stability and drive EGFR (show EGFR ELISA Kits) hyperactivation through enhanced secretion of amphiregulin (show AREG ELISA Kits).

  4. findings uncover functions for iRhom2 in the regulation of EGFR (show EGFR ELISA Kits) signaling and in controlling the activation and substrate selectivity of ADAM17 (show ADAM17 ELISA Kits)-dependent shedding events

  5. mice lacking Rhbdf2 were protected from K/BxN inflammatory arthritis to the same extent as mice lacking TACE (show ADAM17 ELISA Kits) in myeloid cells or Tnfa (show TNF ELISA Kits)-deficient mice

  6. These results establish a specific role for iRhom2 in the secretion of TNFalpha (show TNF ELISA Kits).

  7. iRhom2 is required for TNF (show TNF ELISA Kits) release; iRhom2 binds TACE (show ADAM17 ELISA Kits) and promotes its exit from the ER; failure of TACE (show ADAM17 ELISA Kits) to exit the ER in the absence of iRhom2 prevents the furin (show FURIN ELISA Kits)-mediated maturation and trafficking of TACE (show ADAM17 ELISA Kits) to the cell surface, the site of TNF (show TNF ELISA Kits) cleavage

  8. study reports iRhom2 interacted with TACE (show ADAM17 ELISA Kits) and regulated TNFalpha (show TNF ELISA Kits) shedding; iRhom2 was critical for TACE (show ADAM17 ELISA Kits) maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity

RHBDF2 Antigen Profile

Antigen Summary

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).

Gene names and symbols associated with RHBDF2

  • rhomboid 5 homolog 2 (Drosophila) (RHBDF2) antibody
  • rhomboid 5 homolog 2 (Drosophila) (Rhbdf2) antibody
  • 4732465I17Rik antibody
  • RHBDL5 antibody
  • Rhbdl6 antibody
  • TOC antibody

Protein level used designations for RHBDF2

iRhom2 , inactive rhomboid protein 2 , rhomboid family member 2 , rhomboid veinlet-like protein 5 , rhomboid veinlet-like protein 6 , rhomboid, veinlet-like 6 , rhomboid-like protein 6 , rhomboid-related protein , Rhomboid family member 2 , rhomboid veinlet-like 6

GENE ID SPECIES
79651 Homo sapiens
217344 Mus musculus
483332 Canis lupus familiaris
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