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Rhomboid 5 Homolog 2 (Drosophila) Proteins (RHBDF2)

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Additionally we are shipping RHBDF2 Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHBDF2 79651 Q6PJF5
RHBDF2 217344 Q80WQ6
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Top RHBDF2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

RHBDF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) Interaction Partners

Human Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. results explain how loss of the amino terminus in iRhom1 (show RHBDF1 Proteins) and iRhom2 impairs TNF (show TNF Proteins) signaling, despite enhancing ADAM17 (show ADAM17 Proteins) activity

  2. Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (show ADAM17 Proteins) in epidermal keratinocytes.

  3. Our analyses suggest that these DNA methylation (show HELLS Proteins) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.

  4. RHBDF2 and CYGB (show CYGB Proteins) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.

  5. The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.

Mouse (Murine) Rhomboid 5 Homolog 2 (Drosophila) (RHBDF2) interaction partners

  1. iRhom2 is required for the maturation of TACE (show ADAM17 Proteins) and hair follicle differentiation.

  2. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (show ADAM17 Proteins)-dependent EGFR (show EGFR Proteins) signaling

  3. Rhbdf2 mutations increase its protein stability and drive EGFR (show EGFR Proteins) hyperactivation through enhanced secretion of amphiregulin (show AREG Proteins).

  4. findings uncover functions for iRhom2 in the regulation of EGFR (show EGFR Proteins) signaling and in controlling the activation and substrate selectivity of ADAM17 (show ADAM17 Proteins)-dependent shedding events

  5. mice lacking Rhbdf2 were protected from K/BxN inflammatory arthritis to the same extent as mice lacking TACE (show ADAM17 Proteins) in myeloid cells or Tnfa (show TNF Proteins)-deficient mice

  6. These results establish a specific role for iRhom2 in the secretion of TNFalpha (show TNF Proteins).

  7. iRhom2 is required for TNF (show TNF Proteins) release; iRhom2 binds TACE (show ADAM17 Proteins) and promotes its exit from the ER; failure of TACE (show ADAM17 Proteins) to exit the ER in the absence of iRhom2 prevents the furin (show FURIN Proteins)-mediated maturation and trafficking of TACE (show ADAM17 Proteins) to the cell surface, the site of TNF (show TNF Proteins) cleavage

  8. study reports iRhom2 interacted with TACE (show ADAM17 Proteins) and regulated TNFalpha (show TNF Proteins) shedding; iRhom2 was critical for TACE (show ADAM17 Proteins) maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity

RHBDF2 Protein Profile

Protein Summary

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).

Gene names and symbols associated with RHBDF2

  • rhomboid 5 homolog 2 (Drosophila) (RHBDF2)
  • rhomboid 5 homolog 2 (Drosophila) (Rhbdf2)
  • 4732465I17Rik protein
  • RHBDL5 protein
  • Rhbdl6 protein
  • TOC protein

Protein level used designations for RHBDF2

iRhom2 , inactive rhomboid protein 2 , rhomboid family member 2 , rhomboid veinlet-like protein 5 , rhomboid veinlet-like protein 6 , rhomboid, veinlet-like 6 , rhomboid-like protein 6 , rhomboid-related protein , Rhomboid family member 2 , rhomboid veinlet-like 6

GENE ID SPECIES
79651 Homo sapiens
217344 Mus musculus
483332 Canis lupus familiaris
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