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ROPN1L encodes a member of the ropporin family. Additionally we are shipping Rhophilin Associated Tail Protein 1-Like Proteins (7) and Rhophilin Associated Tail Protein 1-Like Kits (3) and many more products for this protein.
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Human Polyclonal ROPN1L Primary Antibody for EIA, IHC (p) - ABIN954578
Carr, Fujita, Stentz, Liberty, Olson, Narumiya: Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. in The Journal of biological chemistry 2001
Human Polyclonal ROPN1L Primary Antibody for ICC, IF - ABIN4350932
Onoufriadis, Shoemark, Schmidts, Patel, Jimenez, Liu, Thomas, Dixon, Hirst, Rutman, Burgoyne, Williams, Scully, Bolard, Lafitte, Beales, Hogg, Yang, Chung, Emes, OCallaghan, Bouvagnet, Mitchison: Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects. in Human molecular genetics 2014
Sp17 (show SPA17 Antibodies) and ASP (show ASIP Antibodies) cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 (show SPA17 Antibodies) and ASP (show ASIP Antibodies) in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.
Single nucleotide polymorphisms in ROPN1L gene is associated with breast cancer.
Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility.
The beat frequency of cilia from mice lacking ASP (show C3 Antibodies) is significantly slower than wild type, indicating that ASP (show C3 Antibodies) signaling may regulate ciliary motility.
Northern blot analysis of testis RNA from 5-, 15-, 25-, and 40-day-old mice showed expression of the ASP (show C3 Antibodies) gene and in situ hybridization analysis localized the ASP (show C3 Antibodies) mRNA to the germ cell compartment of the seminiferous tubules in the testis
This gene encodes a member of the ropporin family. The encoded protein is a sperm protein. It interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helix domain of AKAP3, which allows PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
, ropporin-1-like protein
, AKAP-associated sperm protein
, A-kinase anchoring protein-associated sperm protein
, ROPN1-like protein
, radial spoke head 11 homolog