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RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Additionally we are shipping Rhotekin Antibodies (37) and Rhotekin Proteins (6) and many more products for this protein.
The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery.
RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2 (show MCM2 ELISA Kits)/3/5, CDK1 (show CDK1 ELISA Kits)/2 and PCNA (show PCNA ELISA Kits)
suggest that interaction of S100A4 (show S100A4 ELISA Kits) and Rhotekin permits S100A4 (show S100A4 ELISA Kits) to complex with RhoA (show RHOA ELISA Kits) and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea
Protein kinase D (show PRKD1 ELISA Kits) regulates RhoA (show RHOA ELISA Kits) activity via phosphorylation rhotekin at Ser (show SIGLEC1 ELISA Kits)-435.
Rho/RTKN-mediated NF-kappaB (show NFKB1 ELISA Kits) activation leading to cell survival may play a key role in gastric tumorigenesis.
These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy.
Lin-7B (show LIN7B ELISA Kits) is a binding partner for Rhotekin in the human brain cDNA library
SEPT9 (show SEPT9 ELISA Kits) sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4 (show SEPT4 ELISA Kits)/SEPT11 (show SEPT11 ELISA Kits) and resistance to Rho/Rhotekin-signaling
Rhotekin forms a complex with vinexin (show Sorbs3 ELISA Kits) and may play a role at focal adhesions.
Loss of miR (show MLXIP ELISA Kits)-145 may provide a selective growth advantage for MCF-7 by targeting RTKN.
these findings suggest that cGK (show PRKG1 ELISA Kits)-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.