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RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Additionally we are shipping Rhotekin Antibodies (39) and many more products for this protein.
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Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.
RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.
The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery.
RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2 (show MCM2 Proteins)/3/5, CDK1 (show CDK1 Proteins)/2 and PCNA (show PCNA Proteins)
suggest that interaction of S100A4 (show S100A4 Proteins) and Rhotekin permits S100A4 (show S100A4 Proteins) to complex with RhoA (show RHOA Proteins) and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea
Protein kinase D (show PRKD1 Proteins) regulates RhoA (show RHOA Proteins) activity via phosphorylation rhotekin at Ser (show SIGLEC1 Proteins)-435.
Rho/RTKN-mediated NF-kappaB (show NFKB1 Proteins) activation leading to cell survival may play a key role in gastric tumorigenesis.
These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy.
Lin-7B is a binding partner for Rhotekin in the human brain cDNA library
SEPT9 (show SEPT9 Proteins) sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4 (show SEPT4 Proteins)/SEPT11 (show SEPT11 Proteins) and resistance to Rho/Rhotekin-signaling
these findings suggest that cGK (show PRKG1 Proteins)-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.