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Ribonuclease H2, Subunit A Proteins (RNASEH2A)

The protein encoded by RNASEH2A is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). Additionally we are shipping RNASEH2A Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNASEH2A 69724 Q9CWY8
RNASEH2A 10535 O75792
Rat RNASEH2A RNASEH2A 364974 Q5U209
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Top RNASEH2A Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,794.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RNASEH2A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Ribonuclease H2, Subunit A (RNASEH2A) Interaction Partners

Mouse (Murine) Ribonuclease H2, Subunit A (RNASEH2A) interaction partners

  1. the G37S mutation of RNaseH2 led to increased expression of interferon (show IFNA Proteins)-stimulated genes dependent on the cGAS-STING signaling pathway.

  2. Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]

  3. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome

  4. Data show that the interwoven architecture of RNase H2B (show RNASEH2B Proteins) and RNase H2C (show RNASEH2C Proteins) that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.

Human Ribonuclease H2, Subunit A (RNASEH2A) interaction partners

  1. RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B (show RNASEH2B Proteins)-dependent manner.

  2. Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA.

  3. study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype

  4. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome

RNASEH2A Protein Profile

Protein Summary

The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Gene names and symbols associated with RNASEH2A

  • ribonuclease H2, subunit A (rnaseh2a)
  • ribonuclease H2, subunit A (RNASEH2A)
  • ribonuclease H2, large subunit (Rnaseh2a)
  • ribonuclease H2, subunit A (Rnaseh2a)
  • 2400006P09Rik protein
  • AGS4 protein
  • JUNB protein
  • RNASEHI protein
  • RNHIA protein
  • RNHL protein
  • zgc:56307 protein

Protein level used designations for RNASEH2A

ribonuclease H2, large subunit , ribonuclease HI, large subunit , RNase H2 subunit A , RNase HI large subunit , ribonuclease H2 subunit A , ribonuclease HI large subunit , ribonuclease HI subunit A , RNase H(35) , aicardi-Goutieres syndrome 4 protein

GENE ID SPECIES
394751 Xenopus (Silurana) tropicalis
455752 Pan troglodytes
69724 Mus musculus
393195 Danio rerio
443655 Xenopus laevis
10535 Homo sapiens
484925 Canis lupus familiaris
512830 Bos taurus
364974 Rattus norvegicus
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