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RNASEH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Additionally we are shipping RNASEH2C Antibodies (19) and RNASEH2C Proteins (4) and many more products for this protein.
This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome.
RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B (show RNASEH2B ELISA Kits)-dependent manner.
Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2.
Describes an RNASEH2C pseudogene that is located close to the SRY (show SRY ELISA Kits) gene on chromosome Y.
Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]
Data show that the interwoven architecture of RNase H2B (show RNASEH2B ELISA Kits) and RNase H2C that interface with RNase H2A (show RNASEH2A ELISA Kits) in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.
RNase H1 small subunit
, RNase H2 subunit C
, aicardi-Goutieres syndrome 3 protein
, ribonuclease H2 subunit C
, ribonuclease HI subunit C
, AYP1 protein