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RNASEH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Additionally we are shipping RNASEH2C Antibodies (18) and many more products for this protein.
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This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C in patients with Aicardi-Goutieres Syndrome.
RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B (show RNASEH2B Proteins)-dependent manner.
Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2.
Describes an RNASEH2C pseudogene that is located close to the SRY (show SRY Proteins) gene on chromosome Y.
Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]
Data show that the interwoven architecture of RNase H2B (show RNASEH2B Proteins) and RNase H2C that interface with RNase H2A (show RNASEH2A Proteins) in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.
RNase H1 small subunit
, RNase H2 subunit C
, aicardi-Goutieres syndrome 3 protein
, ribonuclease H2 subunit C
, ribonuclease HI subunit C
, AYP1 protein