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anti-Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) Antibodies

RNASEL encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Additionally we are shipping RNASEL Proteins (9) and RNASEL Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RNASEL 24014 Q05921
RNASEL 6041 Q05823
RNASEL    
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Top anti-RNASEL Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$229.00
Details
Hamster Mouse Un-conjugated IHC (p), IHC, ELISA, WB RNaseL in transfected cells (0.1 ug) and Hey1B (100 ug), using ABIN151816. RNase L detected in insect cell extracts transfected with recombinant human RNase L. 1 and 0.15 ug of extract. 0.025 mL Log in to see 5 to 7 Days
$140.44
Details
Mouse Rabbit Un-conjugated WB Mouse Rnasel Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mouse Rnasel antibody detected the Mouse Rnasel protein (arrow). Mouse Rnasel Antibody (N-term)  western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Rnasel antibody detected the Rnasel protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged RNASEL is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated ICC, IHC (p), IP, ELISA, WB   100 μg Log in to see 8 to 10 Days
$610.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Hamster Mouse Biotin ELISA, WB   0.1 mL Log in to see 5 to 7 Days
$391.13
Details
Hamster Mouse DyLight 488 ELISA, WB   0.1 mL Log in to see 5 to 7 Days
$427.88
Details
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 2 to 3 Days
$433.13
Details

RNASEL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Top referenced anti-RNASEL Antibodies

  1. Cow (Bovine) Polyclonal RNASEL Primary Antibody for WB - ABIN2792225 : Nakazato, Suzuki, Matsui, Ohtake, Nakata, Yamanaka: Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population. in British journal of cancer 2003 (PubMed)

More Antibodies against RNASEL Interaction Partners

Mouse (Murine) Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon (show IFNA Antibodies) but rather correlates with adequate levels of basal Oas (show SMOC1 Antibodies) gene expression, maintained by basal interferon (show IFNA Antibodies) signaling.

  2. Thus, RNA cleavage events catalyzed by RNase L are required for optimal inflammasome activation during viral infections.

  3. cellular functions of RNase L through protein-protein interactions in the spleen for immune response in mammals

  4. Data indicate that deficiency of 2-5A-dependent RNase L (RNase L) in resulted in a significant delay of diabetes onset.

  5. RNase L contributes to innate immunity through regulating macrophage functions.

  6. By targeting the effector enzyme of this antiviral pathway, L* potently inhibits RNase L, underscoring the importance of this enzyme in innate immunity against Theiler's virus.

  7. RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.

  8. These studies highlight novel roles of RNase L in cigarette smoke plus virus induced inflammation, tissue remodeling, apoptosis, and cytokine elaboration

  9. RNase L activation during mouse hepatitis virus infection is cell type specific and correlates with relatively high levels of expression of oligoadenylate synthetase genes, which are necessary for an effective RNase L antiviral response.

  10. The results suggest that RNase L is not an evolutionarily-conserved host defense mechanism to counteract retroviruses in vivo.

Human Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. This review outlines the role of RNase-L in antimicrobial immunity and the cytoskeleton-associated innate response. [review]

  2. Data show that RNA decay by ribonuclease L (RNase L) has an important role in homeostasis and serves as a suppressor of cell adhesion.

  3. Single Nucleotide Polymorphisms in RNASEL involved in the immune response are generally not associated with intraprostatic inflammation in men without a Prostate cancer diagnosis.

  4. OAS3 (show OAS3 Antibodies) displayed a higher affinity for dsRNA in intact cells than either OAS1 (show OAS1 Antibodies) or OAS2 (show OAS2 Antibodies), consistent with its dominant role in RNase L activation.

  5. Tanslation of vaccinia virus A27L and B5R (show CYB5R3 Antibodies) genes is independent of PKR (show PKLR Antibodies) activation, but their expression is dependent on the RNase L activity.

  6. Our results demonstrate a novel role of RNase L generated small RNAs in cross-talk between autophagy and apoptosis that impacts the fate of cells during viral infections and cancer.

  7. Among 794 RNASEL Ssingle nucleotide polymorphism (SNPs) entries 124 SNPs were found nonsynonymous (ns) from which SIFT predicted 13 nsSNPs as nontolerable whereas PolyPhen-2 predicted 28.

  8. Virus infection and RNase L activation disrupt its association with Filamin A (show FLNA Antibodies) and release RNase L to mediate its canonical nuclease (show DCLRE1C Antibodies)-dependent antiviral activities.

  9. These data show that RNase L targets specific sites in both host and viral RNAs to restrict influenza virus replication when NS1 protein is disabled.

  10. The IFNs inhibit viral infections in part through the 2',5'-oligoadenylate (2-5A) synthetase (OAS (show SMOC1 Antibodies))/RNase L pathway.

Pig (Porcine) Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL) interaction partners

  1. A 2.5 A and 3.25 A X-ray crystal and small-angle X-ray scattering structure of RNase L bound to a natural 2-5A activator with and without ADP or the nonhydrolysable ATP mimetic AMP (show TMPRSS5 Antibodies)-PNP (show NP Antibodies) is functionally characterized.

RNASEL Antigen Profile

Protein Summary

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.

Gene names and symbols associated with RNASEL

  • ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) (Rnasel) antibody
  • ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (RNASEL) antibody
  • E230029I04Rik antibody
  • PRCA1 antibody
  • RNS4 antibody

Protein level used designations for RNASEL

2-5A-dependent RNAase , 2-5A-dependent RNase , 2-5A-dependent ribonuclease , RNase L , ribonuclease 4 , 2',5'-oligoisoadenylate synthetase-dependent , interferon-induced 2-5A-dependent RNase

GENE ID SPECIES
24014 Mus musculus
6041 Homo sapiens
490310 Canis lupus familiaris
100048946 Sus scrofa
100048947 Bos taurus
Selected quality suppliers for anti-RNASEL (RNASEL) Antibodies
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