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Ribonucleotide Reductase M2 Proteins (RRM2)

RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. Additionally we are shipping RRM2 Antibodies (76) and RRM2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RRM2 100359539  
RRM2 6241 P31350
RRM2 20135 P11157
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Top RRM2 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,063.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,072.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,076.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RRM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

Top referenced RRM2 Proteins

  1. Human RRM2 Protein expressed in Escherichia coli (E. coli) - ABIN667014 : Herrick, Sclavi: Ribonucleotide reductase and the regulation of DNA replication: an old story and an ancient heritage. in Molecular microbiology 2007 (PubMed)
    Show all 2 references for ABIN667014

More Proteins for Ribonucleotide Reductase M2 (RRM2) Interaction Partners

Human Ribonucleotide Reductase M2 (RRM2) interaction partners

  1. A significant association has been found between RRM2 rs6759180 (located in the 5'UTR, 10126436G>A) and the risk for developing non-small cell lung cancer.

  2. Data show that ribonucleotide reductase M2 (RRM2) is associated with increased nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)) activity.

  3. our findings establish a signaling role for RRM2 in gastric cancer cells and identify that the RRM2/AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway is essential for tumor invasiveness in gastric cancer cells

  4. HBV exploits the Chk1 (show CHEK1 Proteins)-E2F1 (show E2F1 Proteins) axis of the DNA damage response pathway to induce R2 expression in a cell cycle-independent manner.

  5. High expression level of RRM2 might be negative prognostic factor for resected NSCLC patients.

  6. We suggest that MNNG-stimulated ATR (show ANTXR1 Proteins)/CHK1 (show CHEK1 Proteins) signaling stabilizes E2F3 by S124 phosphorylation, and then E2F3 together with NFY co-transactivate RRM2 expression for DNA repair.

  7. In non-small cell lung cancer, RRM2 expression was predictive of disease-specific survival in women, non-smokers and former smokers. Higher expression was associated with worse survival. This was not the case for men, and current or recently quit smokers.

  8. These results suggested that RRM2 supported the growth of human OSCC cells and that targeting of RRM2, e.g., via GEM (show GEM Proteins) treatment, may be a promising therapeutic strategy for OSCC.

  9. Understanding the role of E2F1 (show E2F1 Proteins) in activating RRM2 transcription will help to explain the relationship between E2F1 (show E2F1 Proteins) and RRM2 in colorectal cancer

  10. R2 and p53R2 (show RRM2B Proteins) small subunits are subject to caspase (show CASP3 Proteins)-dependent degradation

Mouse (Murine) Ribonucleotide Reductase M2 (RRM2) interaction partners

  1. This work reveals that binding of RRM1 (show RRM1 Proteins) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.

  2. mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites

  3. analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (show RRM1 Proteins) and Rrm2 improves cardiac performance

  4. Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.

  5. Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.

  6. illegitimate recombination initiated by c-Myc (show MYC Proteins)

  7. Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (show SRC Proteins) and Erk (show EPHB2 Proteins) Map Kinases.

  8. S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (show E2F1 Proteins)-binding site and an upstream promoter activating region

  9. Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.

  10. results indicate that the affinity of the RNR R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins

Zebrafish Ribonucleotide Reductase M2 (RRM2) interaction partners

RRM2 Protein Profile

Protein Summary

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.

Gene names and symbols associated with RRM2

  • ribonucleotide reductase M2 polypeptide (RRM2)
  • ribonucleotide reductase M2, gene 2 (rrm2.2)
  • ribonucleotide reductase M2, gene 1 (rrm2.1)
  • ribonucleotide reductase M2 (RRM2)
  • ribonucleotide reductase M2 polypeptide (LOC100304963)
  • ribonucleotide reductase M2 polypeptide (LOC100346325)
  • ribonucleotide reductase M2 polypeptide (LOC100359539)
  • ribonucleotide reductase M2 (Rrm2)
  • ribonucleotide reductase M2 polypeptide (rrm2)
  • AA407299 protein
  • cb111 protein
  • chunp6884 protein
  • r2 protein
  • RR2 protein
  • RR2M protein
  • rrm2 protein

Protein level used designations for RRM2

ribonucleotide reductase M2 polypeptide , ribonucleoside-diphosphate reductase subunit M2 , ribonucleotide reductase small chain , ribonucleotide reductase small subunit , ribonucleoside-diphosphate reductase M2 chain , Ribonucleotide reductase 2 , etID309896.20 , reductase M2 polypeptide variant 1 , reductase M2 polypeptide variant 2 , reductase M2 polypeptide variant 3a , reductase M2 polypeptide variant 3b , reductase M2 polypeptide variant 3c , reductase M2 polypeptide variant 3d , ribonucleotide reductase protein r2 class I

GENE ID SPECIES
281468 Bos taurus
380465 Xenopus laevis
394645 Xenopus (Silurana) tropicalis
421936 Gallus gallus
703138 Macaca mulatta
100231721 Taeniopygia guttata
100304963 Ictalurus punctatus
100346325 Oryctolagus cuniculus
100359539 Rattus norvegicus
6241 Homo sapiens
482963 Canis lupus familiaris
100316853 Sus scrofa
508167 Bos taurus
20135 Mus musculus
362720 Rattus norvegicus
30733 Danio rerio
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