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Ring Finger Protein 111 (RNF111) ELISA Kits

The protein encoded by RNF111 is a nuclear RING-domain containing E3 ubiquitin ligase. Additionally we are shipping RNF111 Antibodies (36) and RNF111 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse RNF111 RNF111 93836 Q99ML9
Anti-Human RNF111 RNF111 54778 Q6ZNA4
Anti-Rat RNF111 RNF111 300813  
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More ELISA Kits for RNF111 Interaction Partners

Mouse (Murine) Ring Finger Protein 111 (RNF111) interaction partners

  1. Arkadia, but not the C937A (CA) mutant lacking E3 ubiquitin-ligase activity, induced ubiquitylation and proteasome-dependent degradation of Smad6 (show SMAD6 ELISA Kits).

  2. Arkadia enhances transforming growth factor-beta signaling responses and supports its tumor-suppressing properties in colorectal cancer.

  3. RB1CC1 (show RB1CC1 ELISA Kits) thus appears to play a unique role as a modulator of TGF-beta (show TGFB1 ELISA Kits) signaling by restricting substrate specificity of Arkadia.

  4. Trps1 haploinsufficiency enhances TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.

  5. findings show that Arkadia regulates the levels of expression of c-Ski (show SKI ELISA Kits) protein (show SKIL ELISA Kits) in cell-type-dependent fashion, and exhibits a tumour suppressor function by inhibiting tumour cell growth

  6. Axin (show AXIN1 ELISA Kits) and Arkadia cooperate with each other in promoting Smad7 (show SMAD7 ELISA Kits) ubiquitination.

  7. Arkadia, a nuclear RING-domain E3 ubiquitin ligase, is essential for a subset of Nodal functions in the embryo

  8. Arkadia induces degradation of SnoN (show SKIL ELISA Kits) and c-Ski (show SKI ELISA Kits) in addition to Smad7 (show SMAD7 ELISA Kits).

  9. These results suggest that Arkadia targets Ski (show SKI ELISA Kits)-bound, inactive phospho-Smad2 (show SMAD2 ELISA Kits)/3 to regulate positively Myostatin (show MSTN ELISA Kits)/TGF-beta (show TGFB1 ELISA Kits) signaling.

  10. This work presents an efficient method for expression in E. coli and purification of recombinant Arkadia RING finger (show PCGF1 ELISA Kits) domain as a soluble protein.

Human Ring Finger Protein 111 (RNF111) interaction partners

  1. Results suggest that -459CpG methylation in Sp1 (show PSG1 ELISA Kits)-binding site of RNF111 promoter transcriptionally decreases RNF111 expression, which inhibits TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling associated invasion in NSCLC cells.

  2. Study reports that the monomeric RING domains from the human E3 ligases Arkadia and Ark2C bind directly to free ubiquitin with an affinity comparable to that of other dedicated ubiquitin-binding domains.

  3. These data suggest that RNF111, together with the CRL4(DDB2 (show DDB2 ELISA Kits)) ubiquitin ligase complex, is responsible for sequential XPC (show XPC ELISA Kits) ubiquitylation, which regulates the recruitment and release of XPC (show XPC ELISA Kits) and is crucial for efficient progression of the NER (show NR1H2 ELISA Kits) reaction.

  4. Arkadia can both promote and inhibit gene expression, indicating that Arkadia's activity in transcriptional control may depend on the epigenetic context, defined by Polycomb (show CBX2 ELISA Kits) repressive complexes and DNA methylation (show HELLS ELISA Kits).

  5. Our findings establish RNF111 as a new STUbL that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response.

  6. findings indicate that Arkadia is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis

  7. Arkadia is involved in arsenic-induced degradation of polysumoylated PML (show PML ELISA Kits) protein.

  8. RNF111-dependent neddylation activates DNA damage-induced ubiquitination

  9. FHL2 (show FHL2 ELISA Kits) increases the stability of the TGF-beta (show TGFB1 ELISA Kits) pathway positive regulator Arkadia by inhibiting its ubiquitination and cooperates with Arkadia to activate TGF-beta (show TGFB1 ELISA Kits) signaling.

  10. We established that ARX (show UBA2 ELISA Kits) polyA alterations damage the regulation of KDM5C (show KDM5C ELISA Kits) expression.

RNF111 Antigen Profile

Antigen Summary

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with RNF111

  • ring finger protein 111 (RNF111) antibody
  • hypothetical LOC702104 (RNF111) antibody
  • ring finger protein 111 (rnf111) antibody
  • ring finger protein 111 (LOC100222518) antibody
  • ring finger protein 111 (LOC100357930) antibody
  • ring finger 111 (Rnf111) antibody
  • ring finger protein 111 (Rnf111) antibody
  • ark antibody
  • Arkadia antibody
  • MGC81253 antibody
  • MGC146379 antibody
  • RNF111 antibody

Protein level used designations for RNF111

E3 ubiquitin-protein ligase Arkadia , arkadia , hypothetical LOC702104 , ring finger protein 111 , e3 ubiquitin-protein ligase Arkadia-like , RING finger protein 111 , Arkadia , ring finger 111

GENE ID SPECIES
540353 Bos taurus
374021 Gallus gallus
478323 Canis lupus familiaris
100155446 Sus scrofa
702104 Macaca mulatta
453477 Pan troglodytes
701953 Macaca mulatta
780266 Xenopus (Silurana) tropicalis
100054463 Equus caballus
100222518 Taeniopygia guttata
100357930 Oryctolagus cuniculus
100475090 Ailuropoda melanoleuca
100543062 Meleagris gallopavo
100555431 Anolis carolinensis
100579843 Nomascus leucogenys
93836 Mus musculus
54778 Homo sapiens
300813 Rattus norvegicus
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