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The protein encoded by RNF111 is a nuclear RING-domain containing E3 ubiquitin ligase. Additionally we are shipping RNF111 Antibodies (35) and RNF111 Proteins (3) and many more products for this protein.
Arkadia, but not the C937A (CA) mutant lacking E3 ubiquitin-ligase activity, induced ubiquitylation and proteasome-dependent degradation of Smad6 (show SMAD6 ELISA Kits).
Arkadia enhances transforming growth factor-beta signaling responses and supports its tumor-suppressing properties in colorectal cancer.
RB1CC1 (show RB1CC1 ELISA Kits) thus appears to play a unique role as a modulator of TGF-beta (show TGFB1 ELISA Kits) signaling by restricting substrate specificity of Arkadia.
Trps1 haploinsufficiency enhances TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation.
findings show that Arkadia regulates the levels of expression of c-Ski (show SKI ELISA Kits) protein (show SKIL ELISA Kits) in cell-type-dependent fashion, and exhibits a tumour suppressor function by inhibiting tumour cell growth
Axin (show AXIN1 ELISA Kits) and Arkadia cooperate with each other in promoting Smad7 (show SMAD7 ELISA Kits) ubiquitination.
Arkadia, a nuclear RING-domain E3 ubiquitin ligase, is essential for a subset of Nodal functions in the embryo
Arkadia induces degradation of SnoN (show SKIL ELISA Kits) and c-Ski (show SKI ELISA Kits) in addition to Smad7 (show SMAD7 ELISA Kits).
These results suggest that Arkadia targets Ski (show SKI ELISA Kits)-bound, inactive phospho-Smad2 (show SMAD2 ELISA Kits)/3 to regulate positively Myostatin (show MSTN ELISA Kits)/TGF-beta (show TGFB1 ELISA Kits) signaling.
This work presents an efficient method for expression in E. coli and purification of recombinant Arkadia RING finger (show PCGF1 ELISA Kits) domain as a soluble protein.
Results suggest that -459CpG methylation in Sp1 (show PSG1 ELISA Kits)-binding site of RNF111 promoter transcriptionally decreases RNF111 expression, which inhibits TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling associated invasion in NSCLC cells.
Study reports that the monomeric RING domains from the human E3 ligases Arkadia and Ark2C bind directly to free ubiquitin with an affinity comparable to that of other dedicated ubiquitin-binding domains.
These data suggest that RNF111, together with the CRL4(DDB2 (show DDB2 ELISA Kits)) ubiquitin ligase complex, is responsible for sequential XPC (show XPC ELISA Kits) ubiquitylation, which regulates the recruitment and release of XPC (show XPC ELISA Kits) and is crucial for efficient progression of the NER (show NR1H2 ELISA Kits) reaction.
Arkadia can both promote and inhibit gene expression, indicating that Arkadia's activity in transcriptional control may depend on the epigenetic context, defined by Polycomb (show CBX2 ELISA Kits) repressive complexes and DNA methylation (show HELLS ELISA Kits).
Our findings establish RNF111 as a new STUbL that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response.
findings indicate that Arkadia is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis
Arkadia is involved in arsenic-induced degradation of polysumoylated PML (show PML ELISA Kits) protein.
RNF111-dependent neddylation activates DNA damage-induced ubiquitination
FHL2 (show FHL2 ELISA Kits) increases the stability of the TGF-beta (show TGFB1 ELISA Kits) pathway positive regulator Arkadia by inhibiting its ubiquitination and cooperates with Arkadia to activate TGF-beta (show TGFB1 ELISA Kits) signaling.
We established that ARX (show UBA2 ELISA Kits) polyA alterations damage the regulation of KDM5C (show KDM5C ELISA Kits) expression.
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
E3 ubiquitin-protein ligase Arkadia
, hypothetical LOC702104
, ring finger protein 111
, e3 ubiquitin-protein ligase Arkadia-like
, RING finger protein 111
, ring finger 111