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Acts as an E2-dependent E3 ubiquitin-protein ligase. Additionally we are shipping RNF115 Proteins (3) and many more products for this protein.
Showing 10 out of 39 products:
Cow (Bovine) Polyclonal RNF115 Primary Antibody for WB - ABIN2774716
Sakane, Hatakeyama, Sasaki: Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. in Biochemical and biophysical research communications 2007
Human Polyclonal RNF115 Primary Antibody for ELISA, WB - ABIN188545
Burger, Gao, Amemiya, Kahn, Kitching, Yang, Sun, Narod, Hanna, Seth: A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. in Cancer research 2005
Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha (show NFKBIA Antibodies), which in turn enhances the sequestration of NF-kappaB (show NFKB1 Antibodies) components in the cytoplasm. Since HIV-1 utilizes NF-kappaB (show NFKB1 Antibodies) to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB (show NFKB1 Antibodies) significantly decreases the transcriptional activity of HIV-1.
BCA2 functions as an antiviral factor that targets HIV-1 Gag for degradation, impairing virus assembly and release.
BCA2 is an endogenous inhibitor of AMPK (show PRKAA1 Antibodies) activation in breast cancer cells and BCA2 inhibition increases the efficacy of metformin.
BCA2, a potential oncogenic E3 ubiquitin ligase (show MUL1 Antibodies), promotes breast cancer cell proliferation partially through targeting p21 (show CDKN1A Antibodies) for ubiquitination and proteasomal degradation.
RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors.
High BCA2 expression is associated with renal oncocytoma.
BCA2 is therefore a newly identified transcriptional target of estrogen receptor (show ESR1 Antibodies).
Rabring7 stimulates c-Myc (show MYC Antibodies) degradation via mono-ubiquitination of MM-1 (show PFDN5 Antibodies)
BCA2 accelerates the internalization and degradation of viral particles following their tethering to the cell surface and is a co-factor or enhancer for the tetherin (show BST2 Antibodies)-dependent restriction of HIV-1 release from infected cells.
BCA2 E3 ligase is coregulated with estrogen receptor (show ESR1 Antibodies) and plays a role in the regulation of epidermal growth factor receptor (EGF-R (show EGFR Antibodies)) trafficking
Rabring7 plays crucial roles as a Rab7 (show RAB7A Antibodies) target protein in vesicle traffic to late endosome/lysosome and lysosome biogenesis (rabring7)
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.
E3 ubiquitin-protein ligase RNF115
, rabring 7
, zinc finger protein 364
, Rab7-interacting RING finger protein
, RING finger protein 115
, Rabring 7