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Ring Finger Protein 123 Proteins (RNF123)

The protein encoded by RNF123 contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. Additionally we are shipping RNF123 Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF123 63891 Q5XPI4
RNF123 84585 Q5XPI3
Rat RNF123 RNF123 100190936  
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Top RNF123 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

RNF123 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Ring Finger Protein 123 (RNF123) Interaction Partners

Human Ring Finger Protein 123 (RNF123) interaction partners

  1. Suggest that RNF213 (show RNF213 Proteins) R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia.

  2. Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105 (show CDH13 Proteins), ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50 (show CD40 Proteins).

  3. up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis.

  4. The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations.

  5. Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha (show CBX5 Proteins) and HP1beta (show CBX1 Proteins) upon lamin A/C (show LMNA Proteins) knock-down

  6. This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk.

  7. Dendritic cell apoptosis was at least regulated by miR (show MLXIP Proteins)-221 and miR (show MLXIP Proteins)-155 through targeting the 3'-UTRs of p27kip1 (show CDKN1B Proteins) and Kip1 (show CDKN1B Proteins) ubiquitination-promoting complex 1 (KPC1), respectively.

  8. KPC thus probably controls degradation of p27(Kip1 (show CDKN1B Proteins)) in G1 phase after export of the latter from the nucleus

  9. Free p27 (show PAK2 Proteins) is recognized by the amino-terminal region of KPC1, which also associates with KPC2, and p27 (show PAK2 Proteins) is then polyubiquitylated by the carboxy-terminal RING-finger (show PCGF1 Proteins) domain of KPC1.

RNF123 Protein Profile

Protein Summary

The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1.

Gene names and symbols associated with RNF123

  • ring finger protein 123 (RNF123)
  • ring finger protein 123 (Rnf123)
  • BC003945 protein
  • Kpc1 protein

Protein level used designations for RNF123

E3 ubiquitin-protein ligase RNF123 , kip1 ubiquitination-promoting complex protein 1 , ubiquitin ligase

GENE ID SPECIES
484767 Canis lupus familiaris
100513177 Sus scrofa
63891 Homo sapiens
84585 Mus musculus
100190936 Rattus norvegicus
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