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The protein encoded by RNF123 contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. Additionally we are shipping RNF123 Antibodies (32) and RNF123 Proteins (3) and many more products for this protein.
p27 (show PAK2 ELISA Kits) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (show RCHY1 ELISA Kits), are specifically involved in determining the clinical profiles of lung carcinomas.
RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I (show DDX58 ELISA Kits) and MDA5 (show IFIH1 ELISA Kits), a function that does not depend on its E3 ligase activity.
Suggest that RNF213 (show RNF213 ELISA Kits) R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia.
Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105 (show CDH13 ELISA Kits), ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50 (show CD40 ELISA Kits).
up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis.
The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations.
Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha (show CBX5 ELISA Kits) and HP1beta (show CBX1 ELISA Kits) upon lamin A/C (show LMNA ELISA Kits) knock-down
This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk.
Dendritic cell apoptosis was at least regulated by miR (show MLXIP ELISA Kits)-221 and miR (show MLXIP ELISA Kits)-155 through targeting the 3'-UTRs of p27kip1 (show CDKN1B ELISA Kits) and Kip1 (show CDKN1B ELISA Kits) ubiquitination-promoting complex 1 (KPC1), respectively.
KPC thus probably controls degradation of p27(Kip1 (show CDKN1B ELISA Kits)) in G1 phase after export of the latter from the nucleus
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1.
E3 ubiquitin-protein ligase RNF123
, kip1 ubiquitination-promoting complex protein 1
, ubiquitin ligase