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Ring Finger Protein 125 Proteins (RNF125)

RNF125 encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. Additionally we are shipping RNF125 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF125 67664 Q9D9R0
Rat RNF125 RNF125 361296  
RNF125 54941 Q96EQ8
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Top RNF125 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,581.33
Details

RNF125 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Ring Finger Protein 125 (RNF125) Interaction Partners

Mouse (Murine) Ring Finger Protein 125 (RNF125) interaction partners

  1. Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the ex (show MLXIP Proteins)pression of ring finger protein 125 (RNF125).

  2. RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production

Human Ring Finger Protein 125 (RNF125) interaction partners

  1. we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas

  2. Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR (show MLXIP Proteins)-15b targeting site.

  3. studies of the RNF125 pathway point to upregulation of RIG-I (show DDX58 Proteins)-IPS1 (show MAVS Proteins)-MDA5 (show IFIH1 Proteins) and/or disruption of the PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) and interferon (show IFNA Proteins) signaling pathways as the putative final effectors

  4. In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I (show DDX58 Proteins) is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25 (show TRIM25 Proteins).

  5. study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys (show LYZ Proteins)(48)-linked ubiquitination to retinoic acid-inducible gene-I (show DDX58 Proteins) and leads to the proteasome-dependent degradation of RIG-I (show DDX58 Proteins)

  6. These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway.

  7. TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation

RNF125 Protein Profile

Protein Summary

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Gene names and symbols associated with RNF125

  • ring finger protein 125 (RNF125)
  • ring finger protein 125 (Rnf125)
  • ring finger protein 125, E3 ubiquitin protein ligase (RNF125)
  • 4930553F04Rik protein
  • TRAC-1 protein
  • TRAC1 protein

Protein level used designations for RNF125

E3 ubiquitin-protein ligase RNF125 , T-cell RING activation protein 1 , T-cell ring protein identified in activation screen

GENE ID SPECIES
519541 Bos taurus
67664 Mus musculus
361296 Rattus norvegicus
54941 Homo sapiens
743809 Pan troglodytes
490498 Canis lupus familiaris
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