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RNF125 encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. Additionally we are shipping RNF125 Proteins (4) and many more products for this protein.
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Human Polyclonal RNF125 Primary Antibody for ICC, IF - ABIN4350731
Kim, Frederick, Levesque, Cooper, Feng, Krepler, Brill, Samuels, Hayward, Perlina, Piris, Zhang, Halaban, Herlyn, Brown, Wargo, Dummer, Flaherty, Ronai: Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. in Cell reports 2015
study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 (show TRIM14 Antibodies) in the innate antiviral immune response
Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a (show UTS2R Antibodies)reciprocal correlation between microRNA miR-15b levels and the ex (show MLXIP Antibodies)pression of ring finger protein 125 (RNF125).
RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production
we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas
Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR (show UTS2R Antibodies)) of ring finger protein 125 (RNF125) is a potential microRNA miR (show MLXIP Antibodies)-15b targeting site.
studies of the RNF125 pathway point to upregulation of RIG-I (show DDX58 Antibodies)-IPS1 (show MAVS Antibodies)-MDA5 (show IFIH1 Antibodies) and/or disruption of the PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) and interferon (show IFNA Antibodies) signaling pathways as the putative final effectors
In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I (show DDX58 Antibodies) is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25 (show TRIM25 Antibodies).
study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys (show LYZ Antibodies)(48)-linked ubiquitination to retinoic acid-inducible gene-I (show DDX58 Antibodies) and leads to the proteasome-dependent degradation of RIG-I (show DDX58 Antibodies)
These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway.
TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.
E3 ubiquitin-protein ligase RNF125
, T-cell RING activation protein 1
, T-cell ring protein identified in activation screen