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Ring Finger Protein 128 Proteins (RNF128)

The protein encoded by RNF128 is a type I transmembrane protein that localizes to the endocytic pathway. Additionally we are shipping Ring Finger Protein 128 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF128 66889 Q9D304
RNF128 79589 Q8TEB7
Rat RNF128 RNF128 315911  
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Top Ring Finger Protein 128 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

RNF128 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Ring Finger Protein 128 (RNF128) Interaction Partners

Mouse (Murine) Ring Finger Protein 128 (RNF128) interaction partners

  1. Grail plays a critical role in controlling Th2 cell development through a negative feedback loop by targeting STAT6 (show STAT6 Proteins) for degradation.

  2. GRAIL-expressing T cells expressed regulatory T cell markers and showed suppressive effects in murine dextran sodium salt-induced colitis.

  3. findings reveal a novel association of the increased GRAIL expression with impaired CD4 (show CD4 Proteins) T cell proliferation

  4. Data reveal that GRAIL regulates proteins involved in the actin cytoskeletal organization, thereby maintaining the unresponsive state of anergic T cells.

  5. GRAIL, by mediating TCR-CD3 (show CD3E Proteins) degradation, regulates naive T cell tolerance induction and Treg cell function

  6. a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 (show CD4 Proteins) T cell anergic phenotype in vivo.

  7. Down-regulation of CD40L (show CD40LG Proteins) occurred following ectopic expression of GRAIL in naive T cells from CD40 (show CD40 Proteins)(-/-) mice

  8. GRAIL in the liver is essential for maintenance of normal glucose and lipid metabolism in living animals.

  9. the decline in Th2 cell responsiveness during chronic schistosomiasis is the net result of the upregulation of GRAIL expression in response to repeated antigen stimulation

  10. endogenous GRAIL regulates general cell cycle and proliferation of primary naive CD4 (show CD4 Proteins) T cells.

Human Ring Finger Protein 128 (RNF128) interaction partners

  1. results show that expression of GRAIL is uniquely regulated by the specific miRNA in intestinal mucosa, and suggest that GRAIL may associate with the pathophysiology of Crohn's disease

  2. study shows that Grail has a novel, p53 (show TP53 Proteins)-dependent role in regulating the cell cycle and apoptosis

  3. Forced expression of GRAIL in a T cell line from a T-cell receptor transgenic mouse is sufficient for conversion of these cells to a regulatory phenotype.

  4. Inhibition of T cell activation is not due to apoptosis or disruption of proximal T- cell receptor signaling, but is associated with up-regulation of GRAIL in CD4+ T cells, with modest effects on other E3 ubiquitin ligases.

  5. GRAIL expression was significantly higher in patients with ulcerative colitis in remission than in patients with active disease and in healthy volunteers.

  6. GRAIL captures and then ubiquitinates transmembrane proteins across the cell membrane

  7. endogenous GRAIL regulates general cell cycle and proliferation of primary naive CD4 (show CD4 Proteins) T cells.

  8. GRAIL can down-modulate the expression of CD83 antigen (show CD83 Proteins) on CD4 (show CD4 Proteins) T cells.

Ring Finger Protein 128 (RNF128) Protein Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with RNF128

  • ring finger protein 128a (rnf128a)
  • ring finger protein 128 (RNF128)
  • ring finger protein 128 (Rnf128)
  • ring finger protein 128, E3 ubiquitin protein ligase (RNF128)
  • ring finger protein 128, E3 ubiquitin protein ligase (Rnf128)
  • ring finger protein 128, E3 ubiquitin protein ligase (rnf128)
  • 1300002C13Rik protein
  • AI987883 protein
  • grail protein
  • greul1 protein
  • RGD1566282 protein
  • rnf128 protein
  • wu:fb57h05 protein
  • zgc:77843 protein

Protein level used designations for RNF128

E3 ubiquitin-protein ligase RNF128 , ring finger protein 128 , gene related to anergy in lymphocytes protein , goliath-related E3 ubiquitin-protein ligase 1 , goliath-related E3 ubiquitin ligase 1

GENE ID SPECIES
322325 Danio rerio
422382 Gallus gallus
66889 Mus musculus
79589 Homo sapiens
492051 Canis lupus familiaris
535869 Bos taurus
315911 Rattus norvegicus
779098 Xenopus laevis
100171545 Pongo abelii
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